Current approaches and recommended algorithm for the diagnostic localization of pheochromocytoma

I Ilias, K Pacak - The Journal of Clinical Endocrinology & …, 2004 - academic.oup.com
Pheochromocytomas (PHEO)(1–3) are catecholamineproducing tumors that arise from
chromaffin cells. PHEO are mostly situated within the adrenal medulla, although in about 9 …

[HTML][HTML] Recent advances in radiotracers targeting norepinephrine transporter: structural development and radiolabeling improvements

X Chen, T Kudo, C Lapa, A Buck, T Higuchi - Journal of Neural …, 2020 - Springer
The norepinephrine transporter (NET) is a major target for the evaluation of the cardiac
sympathetic nerve system in patients with heart failure and Parkinson's disease. It is also …

Brown fat imaging with 18F-6-fluorodopamine PET/CT, 18F-FDG PET/CT, and 123I-MIBG SPECT: a study of patients being evaluated for pheochromocytoma

M Hadi, CC Chen, M Whatley, K Pacak… - Journal of Nuclear …, 2007 - Soc Nuclear Med
Several radiopharmaceuticals such as 18F-FDG, 123I-metaiodobenzylguanidine (MIBG),
and 99mTc-tetrofosmin have demonstrated uptake in brown adipose tissue (BAT). It is …

First-in-Human Studies of [18F] Fluorohydroxyphenethylguanidines: Positron Emission Tomography Radiotracers for Quantifying Regional Cardiac Sympathetic …

DM Raffel, YW Jung, RA Koeppe, KS Jang… - Circulation …, 2018 - Am Heart Assoc
Background: Disease-induced damage to cardiac autonomic nerve populations is
associated with an increased risk of sudden cardiac death. The extent of cardiac …

Local sympathetic denervation in painful diabetic neuropathy

CJ Tack, PJ van Gurp, C Holmes, DS Goldstein - Diabetes, 2002 - Am Diabetes Assoc
This study assessed whether painful diabetic neuropathy is associated with abnormal
sympathetic nervous function in the affected limbs. Nine patients with diabetes (four men …

[BOOK][B] Pheochromocytoma: diagnosis, localization, and treatment

K Pacak, G Eisenhofer, J Lenders - 2008 - books.google.com
Pheochromocytomas are rare but treacherous catecholamine-producing tumors, which if
missed or not properly treated, will almost invariably prove fatal. Prompt diagnosis is …

Diagnostic localization of pheochromocytoma: the coming of age of positron emission tomography

K Pacak, G Eisenhofer, JA Carrasquillo… - Annals of the New …, 2002 - Wiley Online Library
Pheochromocytoma is a rare but clinically important tumor of catecholamine‐secreting
chromaffin cells. This tumor constitutes a surgically curable cause of hypertension …

Synthesis and preliminary evaluation of [11C]-(−)-phenylepnrine as a functional heart neuronal PET agent

RB Del Rosario, YW Jung, J Caraher… - Nuclear medicine and …, 1996 - Elsevier
The in vivo behavior of (−)-[11C] phenylephrine (PHEN) is compared with the structurally
similar but monoamine oxidase (MAO)-resistant analog (−)-[11C]-m-hydroxyephedrine …

Novel electrophilic synthesis of 6-[18F]fluorodopamine and comprehensive biological evaluation

O Eskola, TJ Grönroos, A Naum, P Marjamäki… - European journal of …, 2012 - Springer
Abstract Purpose 6-[18 F] Fluorodopamine (4-(2-aminoethyl)-5-[18 F] fluorobenzene-1, 2-
diol, 6-[18 F] FDA) is a tracer for imaging sympathetically innervated tissues. Previous …

Human biodistribution and radiation dosimetry of the tachykinin NK1 antagonist radioligand [18F] SPA-RQ: comparison of thin-slice, bisected, and 2-dimensional …

DR Sprague, FT Chin, JS Liow, M Fujita… - Journal of Nuclear …, 2007 - Soc Nuclear Med
18F-Labeled substance P antagonist–receptor quantifier ([18F] SPA-RQ)[2-fluoromethoxy-5-
(5-trifluoromethyl-tetrazol-1-yl)-benzyl]-[(2 S, 3 S)-2-phenyl-piperidin-3-yl) amine] is a …