The efficacy of chemotherapy for malignant primary or metastatic brain tumours is still poor.
This is at least partly due to the presence of the blood-brain barrier (BBB). The functionality …

Most cancer deaths result from the cancer's either being intrinsically resistant to
chemotherapeutic drugs or becoming resistant after being initially sensitive. Often, in cells …

Abstract Purpose: P-glycoprotein (Pgp) antagonists have had unpredictable
pharmacokinetic interactions requiring reductions of chemotherapy. We report a phase I …

Abstract 99mTc-sestamibi (99mTc-MIBI) is a substrate for the P-glycoprotein (P-gp) pump
but it is not known whether it is a substrate for the multidrug resistance-associated protein …

The multidrug resistant cell line CEM/VBL300 and the parental CEM T-lymphoblastic cell
line from which it was derived were used to study the accumulation of fluorescent …

A major problem in cancer treatment is the development of resistance to multiple
chemotherapeutic agents in tumor cells. A major mechanism of this multidrug resistance …

Abstract 99mTc-sestamibi, a substrate of the multidrug transporter P-glycoprotein (Pgp), has
been used as a functional imaging agent for the multidrug resistance-1 (MDR1) phenotype …

Regadenoson is an FDA approved adenosine receptor agonist which increases blood–
brain barrier (BBB) permeability in rodents. Regadenoson is used clinically for …

The biliary clearance (Clbiliary) of three compounds was estimated using sandwich‐cultured
human hepatocytes (SCHH) and compared with Clbiliary values measured in vivo. Tc‐99m …

Objective To investigate the histopathological features of pathologic parathyroid specimens
associated with negative preoperative technetium Tc 99m sestamibi scans. Design …