PET radiopharmaceuticals: state-of-the-art and future prospects

TJ Tewson, KA Krohn - Seminars in nuclear medicine, 1998 - Elsevier
In this review we provide a conceptual overview of radiopharmaceuticals containing positron-
emitting isotopes, not a catalog of radiopharmaceuticals or details of syntheses. We hope to …

Non-invasive radiotracer imaging as a tool for drug development

RE Gibson, HD Burns, TG Hamill… - Current …, 2000 - ingentaconnect.com
Non-Invasive Radiotracer Imaging (NIRI) uses either short-lived positron-emitting isotopes,
such as 11 C and 18 F, for Positron Emission Tomography (PET) or single photon emitting …

Effects of burn injury, cold stress and cutaneous wound injury on the morphology and energy metabolism of murine brown adipose tissue (BAT) in vivo

EA Carter, AA Bonab, V Hamrahi, J Pitman, D Winter… - Life sciences, 2011 - Elsevier
Aims Cold stress has been shown to produce dramatic increases in 2-fluoro-2-deoxy-D-
Glucose (18 FDG) accumulation by brown adipose tissue (BAT) in rodents. However, neither …

Evaluation of trans-9-18F-fluoro-3, 4-Methyleneheptadecanoic acid as a PET tracer for myocardial fatty acid imaging

TM Shoup, DR Elmaleh, AA Bonab… - Journal of Nuclear …, 2005 - Soc Nuclear Med
This study describes the radiosynthesis and preliminary biologic evaluation of trans-9 (RS)-
18F-fluoro-3, 4 (RS, RS)-methyleneheptadecanoic acid (18F-FCPHA) as a new potential …

Method for monitoring blood flow and metabolic uptake in tissue with radiolabeled alkanoic acid

DR Elmaleh, AJ Fischman, TM Shoup - US Patent 7,494,642, 2009 - Google Patents
The present invention relates to novel modified fatty acid analogs, where a positron or
gamma-emitting label is placed at a position on a fatty acid backbone and an organic …

[PDF][PDF] Influence of blood substrate levels on myocardial kinetics of iodine-123-BMIPP

C Kurata, Y Wakabayashi, S Shouda… - Journal of Nuclear …, 1997 - Soc Nuclear Med
(BMIPP), we examined the correlation between myocardial BMIPP uptake and blood levels
of free fatty acid (FFA), glucose, insulin, triglycĂ© rideand total cholesterol. Methods: In 180 …

Synthesis and preliminary evaluation of [1-11C]hexanoate as a PET tracer of fatty acid metabolism

K Ishiwata, K Ishii, K Ogawa, T Sasaki… - Annals of nuclear …, 1995 - Springer
Abstract The potential of [1-11 C] hexanoate (11 C-HA) as a radiopharmaceutical assessing
fatty acid metabolism of the myocardium and brain tissues by PET studies was evaluated. 11 …

Stereoisomers of fatty acid analogs for diagnostic imaging

DR Elmalch - US Patent 7,005,119, 2006 - Google Patents
The present invention provides novel imaging agents for clinical diagnosis of injuries and
diseases, in the form of a radionuclide in spatial proximity to a substantially pure …

Development of step-specific PET tracers for studying fatty acid β-oxidation: biodistribution of [1-11C] octanoate analogs in rats and a cat

H Kawashima, Y Kuge, K Yajima, Y Miyake… - Nuclear medicine and …, 1998 - Elsevier
To evaluate the potential of [1-11C]-3-(R, S)-methyloctanoate (BMOA),[1-11C]-2-octynoate,
and [1-11C]-2-decynoate as PET tracers for studying particular steps in fatty acid β …

Method for monitoring blood flow and metabolic uptake in tissue with radiolabeled alkanoic acid

DR Elmaleh, AJ Fischman, TM Shoup - US Patent 7,790,142, 2010 - Google Patents
The present invention relates to novel modified fatty acid analogs, where a positron or
gamma-emitting label is placed at a position on a fatty acid backbone and an organic …