Avidin–biotin system for delivery of diagnostic agents

H Sakahara, T Saga - Advanced drug delivery reviews, 1999 - Elsevier
Radiolabeled monoclonal antibodies specific for tumor-associated antigens are used for the
diagnosis and therapy of malignant tumors. However, the blood clearance of antibodies is …

Targeted multifunctional lipid-based nanocarriers for image-guided drug delivery

GA Koning, GC Krijger - Anti-Cancer Agents in Medicinal …, 2007 - ingentaconnect.com
Lipid-based nanocarriers have proven successful in the delivery of mainly chemotherapeutic
agents, and currently they are being applied clinically in the treatment of various types of …

Biochemical modifications of avidin improve pharmacokinetics and biodistribution, and reduce immunogenicity

M Chinol, P Casalini, M Maggiolo, S Canevari… - British journal of …, 1998 - nature.com
Pretargeting techniques using the avidin-biotin system have shown encouraging results in
both diagnostic and therapeutic clinical trials. It has been shown that in cancer therapy the …

[HTML][HTML] Recombinant NeutraLite avidin: a non-glycosylated, acidic mutant of chicken avidin that exhibits high affinity for biotin and low non-specific binding properties

AT Marttila, OH Laitinen, KJ Airenne, T Kulik, EA Bayer… - FEBS letters, 2000 - Elsevier
A recombinant non-glycosylated and acidic form of avidin was designed and expressed in
soluble form in baculovirus-infected insect cells. The mutations were based on the same …

Tumor pretargeting with avidin improves the therapeutic index of biotinylated tumor necrosis factor α in mouse models

A Gasparri, M Moro, F Curnis, A Sacchi, S Pagano… - Cancer research, 1999 - AACR
The clinical use of tumor necrosis factor α (TNF) as an anticancer drug is limited to local or
locoregional administration because of dose-limiting systemic toxicity. We investigated in …

Modulation of the pharmacokinetics of macromolecular contrast material by avidin chase: MRI, optical, and inductively coupled plasma mass spectrometry tracking of …

H Dafni, A Gilead, N Nevo, R Eilam… - … in Medicine: An …, 2003 - Wiley Online Library
The goal of this work was to develop an MRI method for mapping the clearance of interstitial
macromolecular plasma proteins after their extravasation from permeable blood vessels. To …

Tumor pretargeting: role of avidin/streptavidin on monoclonal antibody internalization

P Casalini, E Luison, S Ménard… - The Journal of Nuclear …, 1997 - search.proquest.com
Radioimmunodetection of tumor can be improved by introducing a two-step system in which
radiolabeled streptavidin is administrated after the injection of a biotinylated monoclonal …

Hepatocyte targeting of 111In-labeled oligo-DNA with avidin or avidin–dendrimer complex

M Mamede, T Saga, T Ishimori, T Higashi… - Journal of controlled …, 2004 - Elsevier
To establish an effective nonviral gene transfer vector to hepatocytes, various oligo-carrier
complexes were developed employing dendrimer (G4) and avidin–biotin systems (Av–bt) …

Radiolabeling of avidin with very high specific activity for internal radiation therapy of intraperitoneally disseminated tumors

M Mamede, T Saga, H Kobayashi, T Ishimori… - Clinical cancer …, 2003 - AACR
Purpose: For the effective internal radiation therapy of ip disseminated tumors, we
developed avidin (Av)-dendrimer-chelate complex, which can be labeled with indium-111 …

[PDF][PDF] The relationship of glycosylation and isoelectric point with tumor accumulation of avidin

Z Yao, M Zhang, H Sakahara, Y Nakamoto… - Journal of Nuclear …, 1999 - Soc Nuclear Med
Radiolabeled avidin markedly accumulated in intraperitoneal tumors and was cleared
rapidly from circulation when given intraperitoneally. This study investigated the …