Cutaneous melanoma arises from proliferating melanocytes, cells specialized in the
production of melanin. This property means melanin can be considered as a target for …

Radioiodine-concentrating activity in thyroid tissues has allowed the use of radioiodine as a
diagnostic and therapeutic agent for patients with thyroid disorders such as well …

Dialkylamino-alkyl-benzamides possess an affinity for melanin, suggesting that labeling of
such benzamides with 18F could potentially produce melanin-targeted PET probes able to …

Radiolabeled alpha-melanocyte stimulating hormone (α-MSH) analogues have been used
to define the expression, affinity and function of the melanocortin-1 receptor (MC1-R). The …

Malignant melanoma has one of the highest mortality rates of any cancer because of its
aggressive nature and high metastatic potential. Clinical staging of the disease at the time of …

In order to develop a PET radiopharmaceutical to image malignant melanoma, we
synthesized N-(2-diethylaminoethyl)-4-[18F] fluorobenzamide ([18F]-DAFBA). In vitro studies …

Purpose Radiolabelled benzamides are attractive candidates for targeting melanoma
because they bind to melanin and exhibit high tumour uptake and retention. 18 F-5-Fluoro-N …

Methods: The syntheses and radioiodinationof eight benzamide derivatives are described.
After intravenous injection into C57BI 6-mice subcutaneously transplanted with B16 …

Structure Distribution Relationship of Iodine-123- lodobenzamides as Tracers for the
Detection of Melanotic Melanoma Page 1 Structure Distribution Relationship of Iodine-123lodobenzamides …

Radiolabeled benzamides have been reported to be attractive agents for targeting
malignant melanoma as they bind melanin and display high accumulation in melanoma …