[HTML][HTML] Kinetic modeling and parametric imaging with dynamic PET for oncological applications: general considerations, current clinical applications, and future …

A Dimitrakopoulou-Strauss, L Pan… - European journal of …, 2021 - Springer
Dynamic PET (dPET) studies have been used until now primarily within research purposes.
Although it is generally accepted that the information provided by dPET is superior to that of …

[HTML][HTML] Long axial field of view (LAFOV) PET-CT: implementation in static and dynamic oncological studies

A Dimitrakopoulou-Strauss, L Pan… - European Journal of …, 2023 - Springer
Long axial field of view (LAFOV) PET-CT scanners have been recently developed and are
already in clinical use in few centers worldwide. Although still limited, the hitherto acquired …

Quantifying regional hypoxia in human tumors with positron emission tomography of [18F] fluoromisonidazole: a pretherapy study of 37 patients

JS Rasey, W Koh, ML Evans, LM Peterson… - International Journal of …, 1996 - Elsevier
Purpose: To assess pretreatment hypoxia in a variety of tumors using positron emission
tomography (PET) after injection of the hypoxia-binding radiopharmaceutical [“'F] …

Imaging P‐glycoprotein transport activity at the human blood‐brain barrier with positron emission tomography

L Sasongko, JM Link, M Muzi… - Clinical …, 2005 - Wiley Online Library
Background Numerous knockout mouse studies have revealed that P‐glycoprotein (P‐gp)
significantly limits drug distribution across the mouse blood‐brain barrier (BBB). To …

In Vivo Validation of 3′deoxy-3′-[18F]fluorothymidine ([18F]FLT) as a Proliferation Imaging Tracer in Humans: Correlation of [18F]FLT Uptake by …

H Vesselle, J Grierson, M Muzi, JM Pugsley… - Clinical cancer …, 2002 - AACR
Purpose: Tumor proliferation has prognostic value in resectedearly stage non-small cell lung
cancer (NSCLC) and can, therefore, predict which NSCLCs are at high risk for recurrence …

18F-FDG PET of gliomas at delayed intervals: improved distinction between tumor and normal gray matter

AM Spence, M Muzi, DA Mankoff… - Journal of Nuclear …, 2004 - Soc Nuclear Med
We hypothesized that delineation of gliomas from gray matter with 18F-FDG PET could be
improved by extending the interval between 18F-FDG administration and PET data …

Characteristics of a new fully programmable blood sampling device for monitoring blood radioactivity during PET

R Boellaard, A van Lingen, SCM van Balen… - European journal of …, 2001 - Springer
The first performance tests of a new fully programmable blood sampling device for
monitoring blood radioactivity during positron emission tomography (PET) are described …

Imaging of cyclosporine inhibition of P-glycoprotein activity using 11C-verapamil in the brain: studies of healthy humans

M Muzi, DA Mankoff, JM Link, S Shoner… - Journal of Nuclear …, 2009 - Soc Nuclear Med
The multiple-drug resistance (MDR) transporter P-glycoprotein (P-gp) is highly expressed at
the human blood–brain barrier (BBB). P-gp actively effluxes a wide variety of drugs from the …

Kinetic analysis of 3′-deoxy-3′-18F-fluorothymidine in patients with gliomas

M Muzi, AM Spence, F O'Sullivan… - Journal of Nuclear …, 2006 - Soc Nuclear Med
3′-Deoxy-3′-fluorothymidine (FLT), a thymidine analog, is under investigation for
monitoring cellular proliferation in gliomas, a potential measure of disease progression and …

The FDG lumped constant in normal human brain

MM Graham, M Muzi, AM Spence… - Journal of Nuclear …, 2002 - Soc Nuclear Med
The lumped constant (LC) is a correction factor used to infer glucose metabolic rate (MRglc)
from FDG metabolic rate (MRFDG). Methods: LC was determined in normal brain in 10 …