Decreased tissue oxygen tension is a component of many diseases. Although hypoxia can
be secondary to a low inspired P0 2 or a variety of lung disorders, the commonest cause is …

Inherent in the application of advances in biomedical science to nuclear medicine is the
concept of molecular targeting: the in vivo concentration of labeled tracer by a gene, its …

MISO in vitro into EMT6 cells was investigated at the dissolved oxygen concentrations of 0, 1
x to3, 5 x 103, 5 x 10" and 2 x 105 ppm. Biodistribution performed at 1, 5, 10, 20 and 40 min …

This article reviews possible use of 18F-labelled radiopharmaceuticals in oncology with
positron emission tomography. The characteristics of various 18F-labelled compounds are …

Myocardial hypoxia is a major factor in the pathology of cardiac ischemia and myocardial
infarction. Hypoxia also occurs in microvascular disease and cardiac hypertrophy, and is …

Tumour hypoxia is thought to contribute to some failures of radiotherapy to achieve local
control. Polarographic measurements of tumour oxygenation have been shown to predict …

Abstract Copper-62 labeled diacetyl-bis (N 4-methylthiosemicarbazone)(62 Cu-ATSM) has
been proposed as a generator produced positron-emitting tracer for hypoxic tissue imaging …

A series of radiopharmaceuticals that incorporate nitroimidazole moieties have
beensynthesized to detect decreased local tissue pO2. In contrast to agents that localize in …

Fluorine-18 labelled fluoromisonidazole ([18 F] FMISO) has been shown to accumulate in
hypoxic tissue in inverse proportion to tissue oxygenation. In order to evaluate the potential …

OBJECTIVES: Tumor growth beyond the region where vascular oxygen can reach creates a
hypoxic domain. In this study, BnAO, a ligand that had been labeled with 99mTc …