Bilirubin, a breakdown product of heme, is normally glucuronidated and excreted by the liver
into bile. Failure of this system can lead to a buildup of conjugated bilirubin in the blood …

Hepatocyte transporters control the hepatobiliary elimination of many drugs, metabolites,
and endogenous substances. Hepatocyte transporter function is altered in several …

Organic anion transporting polypeptide (OATP) transporters expressed in the liver and
intestine mediate the uptake of many clinically important drugs. Impaired transport function …

ORAL BIOAVAILABILITY AND DRUG DELIVERY Improve the performance and viability of
newly-developed and approved drugs with this crucial guide Bioavailability is the parameter …

Recent improvements in hepatobiliary radiopharmaceuticals and the high prevalence of
biliary tract disease have resulted in a larger role for hepatobiliary imaging in clinical …

The kinetics of 99mTc-Trimethyl-Br-IDA blood clearance was analysed in the rat 24 h after
warm ischaemia and reperfusion of the liver. There were changes in the elimination of …

A 7‐year‐old girl had been followed up for persistent conjugated hyperbilirubinemia since
birth. Alanine aminotransferase, aspartate aminotransferase and γ‐glutamyl transpeptidase …

Rotor syndrome is an inheritable disorder of bilirubin metabolism characterized by a chronic,
benign, nonhemolytic jaundice, due to raised, predominantly direct bilirubin. It is considered …

Rotor Syndrome (RS) is a rare disease that is autosomal recessive and characterized by
asymptomatic jaundice, conjugated hyperbilirubinemia and coproporphyria. RS occurs as a …