Alzheimer's disease (AD) is the most prevalent form of dementia. Despite decades of
research following several theoretical and clinical lines, all existing treatments for the …

This review describes recent developments in the chemistry of both first and second
generation 99m-technetium-based imaging agents. The material is presented according to …

There has been increasing awareness that some slowly progressive focal cortical
syndromes can be the presenting features of Alzheimer's disease, but pathological evidence …

Radiopharmaceuticals, drugs containing a radionu-clide, are used routinely in nuclear
medicine depart-ments for the diagnosis of disease and are under investigation for use in …

Background Regional cerebral perfusion measured by single photon emission computed
tomography (SPECT) was examined as a preclinical predictor of the development of …

The purpose of this study was to confirm with pathologic verification 2 beliefs related to
Alzheimer's disease (AD):(a) the long-standing impression that bilateral temporo-parietal …

Background Mild cognitive impairment (MCI) was recently described as a heterogeneous
group with a variety of clinical outcomes and high risk to develop Alzheimer's disease (AD) …

Objective: Numerous studies have suggested that temporoparietal hypoperfusion seen on
brain imaging with SPECT may be useful in diagnosing AD during life. However, these …

OBJECTIVE: To evaluate the clinical course and predictors of outcome in outpatients with
cognitive impairment who do not meet criteria for dementia at initial evaluation. DESIGN …

In mild-to-moderate Alzheimer's disease, previous PET studies failed to reveal significant
involvement in the medial temporal lobe having pathologically neurodegenerative changes …