Successful treatment of cancer patients requires balancing of the dose, timing, and type of
therapeutic regimen. Detection of increased cell death may serve as a predictor of the …

Myocardial necrosis plays an important role in the pathogenesis of various cardiovascular
disorders and can result from different myocardial insults. Its non-invasive identification and …

Copper labeled diacetyl-bis (N4-methylthiosemicarbazone)(Cu-ATSM) is a promising agent
for the imaging of hypoxic tissues. In the present study 64Cu (t1/2= 12.8 h) labeled Cu-ATSM …

Abstract Aims Mono-[123I] iodohypericin ([123I] MIH) has been reported to have high avidity
for necrosis. In the present study, by using rabbit models of acute myocardial infarction, we …

Background 99mTc glucarate has recently been reported to be an infarct-avid agent. The
feasibility of imaging with 99mTc glucarate was evaluated for the early diagnosis of …

Background. Noninvasive imaging techniques would be highly desirable to differentiate
oncotic from apoptotic cell death. Indium 111 antimyosin and technetium 99m glucaric acid …

99mTc-Glucarate is an infarct-avid imaging agent with the potential for very early detection
of myocardial infarction. The purposes of this study using a canine model were to determine …

Tc-99m pyrophosphate is the grandfather of infarct avid agents. Its value is its clinical
availability and ease of use. However, its shortcomings are the delay of 2 to 3 days for …

Objective: Recently 99mTc-glucarate, a radiolabeled glucose analogue, has been
considered as a SPECT alternative to 18F-FDG and PET for non-invasive detection of …

Purpose: After acute arterial obstruction of the lower extremity, muscle damage is the critical
determinant for clinical outcome. The extent of muscle damage and limb viability are …