Accurate estimation of the 3D in vivo activity distribution is important for dose estimation in
targeted radionuclide therapy (TRT). Although SPECT can potentially provide such …

Purpose: A phase I trial that evaluated for extrahe-matopoietic toxicity was conducted with
iodine-131 (1311) labeled monoclonal antibody (MAb) CC49. Correlative studies included …

IgG. Methods: Whole-body imaging of 12 patients, who received 111-185 MBq (3-5 mCi) of
111ln-CC49, commenced in< 2 hr postinfusion and was continued daily for 4-5 days …

Indium 111 SPECT allows one to determine the activity distribution of tracers used in
radioimmunotherapy, such as Zevalin® labeled with yttrium 90. Using computer simulations …

Promising response rates are noted in patients with refractory Hodgkin's disease after
radioimmunoglobulin therapy (RIT) with Yttrium-90 labeled polyclonal antiferritin. To explore …

High-dose radiation therapy for liver metastases of gastrointestinal malignancies might be
improved by combining external-beam irradiation and radioimmunoglobulin therapy. We …

Translational research supports the use of radiolabeled antiferritin for recurrent Hodgkin's
disease. A 60% tumor response rate is obtained after treatment of out-patients with …

Abstract B72. 3, a monoclonal antibody with reactivity against human adenocarcinomas was
obtained from the Cytogen Corporation in the form of an immunoconjugate coupled with …

Human tumors express antigenic sites that can serve as targets for radiolabeled monoclonal
antibodies for diagnosis, therapy and biologic characterization of human tumors in vivo …

Accurate and reproducible quantification of tumor radioactivity by imaging requires definition
of a region of interest (ROI) for the tumor. The use of a threshold for creating the tumor ROI …