Advances in imaging brain metabolism

F Hyder, DL Rothman - Annual review of biomedical …, 2017 - annualreviews.org
Metabolism is central to neuroimaging because it can reveal pathways by which neuronal
and glial cells use nutrients to fuel their growth and function. We focus on advanced …

[HTML][HTML] Blood-brain glucose transfer in Alzheimer's disease: effect of GLP-1 analog treatment

M Gejl, B Brock, L Egefjord, K Vang, J Rungby… - Scientific reports, 2017 - nature.com
There are fewer than normal glucose transporters at the blood-brain barrier (BBB) in
Alzheimer's disease (AD). When reduced expression of transporters aggravates the …

Quantitative rates of brain glucose metabolism distinguish minimally conscious from vegetative state patients

J Stender, R Kupers, A Rodell… - Journal of Cerebral …, 2015 - journals.sagepub.com
The differentiation of the vegetative or unresponsive wakefulness syndrome (VS/UWS) from
the minimally conscious state (MCS) is an important clinical issue. The cerebral metabolic …

Uniform distributions of glucose oxidation and oxygen extraction in gray matter of normal human brain: no evidence of regional differences of aerobic glycolysis

F Hyder, P Herman, CJ Bailey… - Journal of Cerebral …, 2016 - journals.sagepub.com
Regionally variable rates of aerobic glycolysis in brain networks identified by resting-state
functional magnetic resonance imaging (R-fMRI) imply regionally variable adenosine …

[PDF][PDF] The minimal energetic requirement of sustained awareness after brain injury

J Stender, KN Mortensen, A Thibaut, S Darkner… - Current Biology, 2016 - cell.com
Differentiation of the minimally conscious state (MCS) and the unresponsive wakefulness
syndrome (UWS) is a persistent clinical challenge [1]. Based on positron emission …

Metabolic derangements are associated with impaired glucose delivery following traumatic brain injury

J Hermanides, YT Hong, M Trivedi, J Outtrim… - Brain, 2021 - academic.oup.com
Metabolic derangements following traumatic brain injury are poorly characterized. In this
single-centre observational cohort study we combined 18F-FDG and multi-tracer oxygen-15 …

[PDF][PDF] Fluorine-18-fluorodeoxyglucose PET to determine regional cerebral glucose utilization: a re-examination

KC Schmidt, G Lucignani, L Sokoloff - Journal of Nuclear Medicine, 1996 - Soc Nuclear Med
PET SCANNERS Recent generations of scanners are more efficient and contain multiple-
rings that allow many planes to be scanned simulta neously in much shorter time intervals …

Errors Introduced by Tissue Heterogeneity in Estimation of Local Cerebral Glucose Utilization with Current Kinetic Models of the [18F]Fluorodeoxyglucose Method

K Schmidt, G Lucignani, RM Moresco… - Journal of Cerebral …, 1992 - journals.sagepub.com
The effects of tissue heterogeneity on the estimation of regional cerebral glucose utilization
(rCMRglc) in normal humans with [18F] 2-fluoro-2-deoxy-d-glucose ([18F] FDG) and positron …

Quantitative positron emission tomography reveals regional differences in aerobic glycolysis within the human brain

T Blazey, AZ Snyder, Y Su, MS Goyal… - Journal of Cerebral …, 2019 - journals.sagepub.com
Glucose and oxygen metabolism are tightly coupled in the human brain, with the
preponderance of the brain's glucose supply used to generate ATP via oxidative …

[HTML][HTML] Concurrent imaging of vascularization and metabolism in a mouse model of paraganglioma under anti-angiogenic treatment

C Facchin, M Perez-Liva, A Garofalakis, T Viel… - Theranostics, 2020 - ncbi.nlm.nih.gov
Rationale: Deregulation of metabolism and induction of vascularization are major hallmarks
of cancer. Using a new multimodal preclinical imaging instrument, we explored a sequence …