During the past decade, considerable efforts have been made in the development of
radiopharmaceuticals for thein vivo study of the cholinergic neurotransmission using …

Major tracers for probing regional metabolism and neuroreceptor binding in brain and heart
with positron emission tomography (PET) and single photon emission tomography (SPET) …

The aberrant expression and function of certain receptors in tumours and other diseased
tissues make them preferable targets for molecular imaging. PET and SPECT radionuclides …

The synthesis and preliminary biological characterization of two isomeric technetium labeled
complexes (2, 5, 5, 9-tetramethyl-4, 7-diaza-7-(3′(R)-quinuclidinylcarboxymethyl)-2, 9 …

Neuroreceptor imaging is increasing in nuclear medicine. New generations of radioligands
will be developed that will allow us to study neurotransmitter systems not studied before. In …

The neurotransmitter acetylcholine (ACh) is widely distributed within the central nervous
system (CNS) and is involved in a number of important processes, including roles in sensory …

Upregulation of muscarinic cholinergic receptors (mAChR) after chronic atropine treatment
has been described previously. The present study was designed to evaluate 4-iodine-125 …

4-[76Br] bromodexetimide and its inactive enantiomer 4-[76Br] bromolevetimide were
prepared via electrophilic bromodesilylation using chloramine-T and no-carrier-added …

Cardiac muscarinic receptor ligands suitable for positron emission tomography have
previously been characterised. Attempts to develop radioligands of these receptors suitable …

[123I] N-methyl-4-iododexetimide,[123I] MIDEX, and its pharmacologically inactive
enantiomer [123I] N-methyl-4-iodolevetimide,[123I] MILEV were prepared via electrophilic …