Safety, pharmacokinetic and dosimetry evaluation of the proposed thrombus imaging agent 99mTc-DI-DD-3B6/22-80B3 Fab′

DJ Macfarlane, RC Smart, WW Tsui… - European journal of …, 2006 - Springer
Abstract Purpose 99m Tc-DI-DD-3B6/22-80B3 (Thromboview, hereafter abbreviated to 99m
Tc-DI-80B3 Fab′) is a humanised, radiolabelled monoclonal antibody Fab′ fragment with …

Degree of polymer organization decreases the binding of a monoclonal antibody raised against the β-chain amino terminus of fibrin

TA Morris, JJ Marsh, R Fagnani… - Thrombosis and …, 1997 - thieme-connect.com
Accurate non-invasive diagnosis of deep venous thrombosis and pulmonary embolism
remains an elusive goal. Radiolabeled antibodies specific for the epitope exposed on the β …

The safety and pharmacokinetics in adult subjects of an intravenously administered 99mTc-labeled 17 amino acid peptide (CYT-379)

S Ben-Haim, D Kahn, GJ Weiner, MT Madsen… - Nuclear medicine and …, 1994 - Elsevier
A phase I study was designed to evaluate the safety and pharmacokinetics of a novel
platelet reactive peptide, peptide acetyl-SYGRGDVRGDFKCTCCA-amide (CYT-379), which …

Investigation of suspected lower limb venous thrombosis.

GR Sissons - Annals of the Royal College of Surgeons of England, 1998 - ncbi.nlm.nih.gov
As well as being a common preterminal event, venous thromboembolism remains a major
preventable cause of morbidity and mortality (1, 2). Prevention of the disease in those at …

Diagnosis and treatment of pulmonary embolism

S Koerner - Cardiology Clinics, 1991 - cardiology.theclinics.com
Because pulmonary embolism is the result of deep venous thrombosis (DVT), predominantly
of the lower extremities, prevention of DVT in patients who are at high risk is important …

Detection of deep venous thrombosis with indium 111-labelled monoclonal antibody against tissue plasminogen activator

N Tromholt, B Hesse, O Folkenborg, J Selmer… - European journal of …, 1991 - Springer
The administration of a radiolabelled monoclonal antibody against tissue plasminogen
activator allows detection of areas with increased fibrinolytic activity, ie those with an active …

[PDF][PDF] Evidence for the prolongation of aspirine induced modifications in human blood

R Curini, G D'Ascenzo, A Fraioli, A Gentili… - …, 1999 - analusis.edpsciences.org
Aspirin is a common drug for very different purposes: it can be used for colds, for headaches,
but its giving is even the usual applied therapy either for the prevention or for the …

Experimentally produced pulmonary arterial occlusion in the dog: identification with pertechnegas inhalation.

EM Scalzetti, ZD Grossman, GM Gagne - Radiology, 1993 - pubs.rsna.org
Pertechnegas, a variant of technegas, is a fine, dry aerosol formed when technetium-99m
pertechnetate is vaporized in a technegas generator under appropriate conditions. After …

[CITATION][C] Will a radiolabeled antibody replace indium-111-platelets to detect active thrombus?

JE Seabold, SF Rosebrough - Journal of Nuclear Medicine, 1994 - Soc Nuclear Med
M. this issue of the Journal calls at tention to apersistent challenge facing nuclear medicine:
the quest for a reli able imaging agent to detect active and mature thrombi that will contribute …

[CITATION][C] 肺动脉栓塞和下肢深静脉血栓的放射性核素显像进展 (文献综述)

瞿卫, 王自正, 王峰 - 放射免疫学杂志, 2008 - cqvip.com
肺动脉栓塞简称为肺栓塞(PE), 其与下肢深静脉血栓(DVT) 同属于血栓性疾病,
是临床上一种致死率, 致残率较高的常见病, 多发病. 美国每年估计约有60 万新发患者 …