Lipoproteins and lipoprotein mimetics for imaging and drug delivery

CS Thaxton, JS Rink, PC Naha, DP Cormode - Advanced drug delivery …, 2016 - Elsevier
Lipoproteins are a set of natural nanoparticles whose main role is the transport of fats within
the body. While much work has been done to develop synthetic nanocarriers to deliver …

Modified natural nanoparticles as contrast agents for medical imaging

DP Cormode, PA Jarzyna, WJM Mulder… - Advanced drug delivery …, 2010 - Elsevier
The development of novel and effective contrast agents is one of the drivers of the ongoing
improvement in medical imaging. Many of the new agents reported are nanoparticle-based …

Radiolabeled liposomes and lipoproteins as lipidic nanoparticles for imaging and therapy

L Aranda-Lara, E Morales-Avila… - Chemistry and Physics …, 2020 - Elsevier
Radiolabeled lipidic nanoparticles, particularly liposomes and lipoproteins, are of great
interest as agents for imaging and therapy, due not only to their peculiar physicochemical …

Imaging atherosclerosis and vulnerable plaque

MM Sadeghi, DK Glover, GM Lanza… - Journal of Nuclear …, 2010 - Soc Nuclear Med
Identifying patients at high risk for an acute cardiovascular event such as myocardial
infarction or stroke and assessing the total atherosclerotic burden are clinically important …

High-density lipoprotein–based contrast agents for multimodal imaging of atherosclerosis

T Skajaa, DP Cormode, E Falk… - … , and vascular biology, 2010 - Am Heart Assoc
Lipoproteins, natural nanoparticles, have a well-recognized biological role and are highly
suitable as a platform for delivering imaging agents. The ease with which both the exterior …

Molecular and metabolic imaging of atherosclerosis

JR Davies, JH Rudd, PL Weissberg - Journal of Nuclear Medicine, 2004 - Soc Nuclear Med
Atherosclerosis is a systemic disease that affects most major arteries of the body and is the
most common cause of premature death in the western world. It develops slowly and often …

2 Clinically useful chelators of tripositive elements

RC Hider, AD Hall - Progress in medicinal chemistry, 1991 - Elsevier
Publisher Summary This chapter discusses the clinically useful chelators of tripositive
elements. The clinical use of chelator molecules has been synonymous with the removal of …

Radiolabeled MDA2, an oxidation-specific, monoclonal antibody, identifies native atherosclerotic lesions in vivo

S Tsimikas, W Palinski, SE Halpern, DW Yeung… - Journal of Nuclear …, 1999 - Springer
Background Oxidatively modified low-density lipoprotein (LDL) is present in atherosclerotic
but not normal arteries and plays a crucial role in the pathogenesis and adverse …

Lipoprotein-related and apolipoprotein-mediated delivery systems for drug targeting and imaging

G Almer, H Mangge, A Zimmer… - Current medicinal …, 2015 - ingentaconnect.com
The integration of lipoprotein-related or apolipoprotein-targeted nanoparticles as
pharmaceutical carriers opens new therapeutic and diagnostic avenues in nanomedicine …

Processing of antibody‐radioisotope conjugates after binding to the surface of tumor cells

M Jules Mattes, GL Griffiths, H Diril, DM Goldenberg… - cancer, 1994 - Wiley Online Library
Background. Previous experiments indicated that most antibodies binding to cell surface
antigens are internalized gradually and degraded within lysosomes, with a half‐life of …