Radiopharmaceutical therapy (RPT) is emerging as a safe and effective targeted approach
to treating many types of cancer. In RPT, radiation is systemically or locally delivered using …

The antitumor ether lipid ET-18-OCH3 (edelfosine) is the prototype of a new class of
antineoplastic agents, synthetic analogues of lysophosphatidylcholine, that shows a high …

Radioiodinated phospholipid ether analogues have shown a remarkable ability to
selectively accumulate in a variety of human and animal tumors in xenograft and …

Radioiodinated phospholipid ethers have shown the remarkable ability to selectively
accumulate in a variety of animal tumors as well as in humantumor xenografts. It has been …

Prostate cancer is a heterogeneous disease, and its management is now evolving to
become more personalized and to incorporate new targeted therapy. With these new …

The present invention provides methods for treating, detecting and locating recurrence of
cancer, radiation and chemo insensitive cancer or metastasis of cancer selected from the …

We have designed and synthesized two radioiodinated analogs of
hexadecylphosphocholine in order to evaluate their tumor imaging potential. 12-(m [125 I] …

MATERIALS AND METhODS Preparation of Iodine-125-NM324 Radioiodinated NM324 was
made via isotope exchange in pivalic acid (24). Briefly, unlabeled l2-(m-iodophenyl) dodecyl …

Previous work has shown that radioiodinated phospholipid ether analogs with the iodine-
125 substituted on the meta position of the aromatic ring readily localized in a variety of …

NM-294 was synthesized as previously described (4). Purity and proof of structure were
determined by proton nuclear mag netic resonance, infrared analysis, elemental analysis …