Tumor receptors play an important role in carcinogenesis and tumor growth and have been
some of the earliest targets for tumor-specific therapy, for example, the estrogen receptor in …

Over the last several decades, significant “new eyes” have been developed that improve the
diagnosis, treatment, planning, and monitoring of human cancer: computer tomography …

A-ring fluorination of estradiol (ES) at position 2 or 4 decreases the rate of metabolism by
blocking the formation of catechol estrogens, one of the major metabolic pathways of ES. We …

Alkaloid-, steroid-, biotin-, carbohydrate-, nucleoside-, and peptide-based bioconjugates are
easily labeled with CO by a last-step palladium-catalyzed carbonylation. The choice of the …

In the past four years most of the effort in radiopharmaceutical chemistry has been devoted
to compounds for positron emission tomography, but widespread use of this technique is still …

The 3-D quantitative structure-activity relationships/comparative molecular field analysis
(QSAR/CoMFA) paradigm, which considers the primary importance of the molecular fields in …

To assess the feasibility of using estrogen receptor-directed therapy with Auger electron-
emitting ligands for therapy of estrogen receptor (ER)-containing cancers, we synthesized …

We prepared the 2, 16α-and 4, 16α-difluoroestradiols and their 11β-methoxy derivatives via
two different pathways. The first route permits large scale synthesis and characterization of …

The ability to measure biochemical and molecular processes underlies progress in breast
cancer biology and treatment. These assays have traditionally been performed by analysis …

The fast, efficient, and functional group tolerant last-step radiolabeling of bioconjugates is
crucial for positron emission tomography (PET) applications. In this context, o-iodobenzyl …