Pretargeted nuclear imaging and radiotherapy have recently attracted increasing attention
for diagnosis and treatment of cancer with nanomedicines. This is because it conceptually …

Gadolinium-based MRI contrast agents (CAs) can be effective at a∼ 100-fold lower
concentration of Gadolinium ions in comparison to the concentration of Iodine atoms …

A Phase II study of yttrium-90-tetra-azacyclododecanetetra-acetic acid-biotin (90Y-DOTA-
biotin) pretargeted by NR-LU-10 antibody/streptavidin (SA) was performed. The primary …

Monoclonal antibodies to tumour-associated antigens have great theoretical potential for the
specific targeting of radioactivity and anti-neoplastic agents to tumours. The clinical success …

Type 1 diabetes mellitus (T1DM) is an autoimmune disease caused by autoreactive T cells
targeting the insulin-producing beta (β) cells. Despite advances in insulin therapy, T1DM still …

Antibodies have long been viewed as potential agents for targeted drug delivery and other
therapeutic interventions, largely with a view to exploiting the combination of high specificity …

Paramagnetic metals can induce T1 shortening by interaction with free water molecules.
Two metal ions, Gadolinium and Manganese, are currently available for human use …

Angiogenesis is essential for tumor growth and metastatic potential and for that reason
considered an important target for tumor treatment. Noninvasive imaging technologies …

We are investigating the hypothesis that biotin multimers can be used with streptavidin and
monoclonal antibody conjugates in cancer pretargeting protocols to provide a method of …

Radiolabeled monoclonal antibodies specific for tumor-associated antigens are used for the
diagnosis and therapy of malignant tumors. However, the blood clearance of antibodies is …