Receptor-based radiopharmaceuticals are of great current interest in molecular imaging and
radiotherapy of cancers, and provide a unique tool for target-specific delivery of …

Coordination compounds of the radioactive element technetium are well established in
diagnostic nuclear medicine, and various complexes of the gamma-emitting nuclide 99mTc …

Peptides are compounds that contain amino acids (R-aminocarboxylic acids) linked by
amide (peptide) bonds. Designed by nature for stimulating, inhibiting, or regulating …

Technetium-99m (99m Tc) mercaptoacetyltriglycine (MAG 3) is a new renal
radiopharmaceutical that was recently introduced as a 99m Tc-labeled replacement for …

About 14 years have passed since Fritzberg et al. developed 99m Tc-MAG3 in 1986. The
biological properties of this radiopharmaceutical are somewhat different from radioiodine …

Metallic radionuclides have been instrumental in the field of nuclear imaging for over half a
century. While recent years have played witness to a dramatic rise in the use of radiometals …

Recently, complementary DNA (cDNA) encoding ap-aminohippurate (PAH) transporter
designated rat organic anion transporter 1 (OAT1) was isolated. OAT1, a multispecific …

The chemistry behind the development of technetium-99m (Tc-99m) complexes useful for
determining renal (kidney) function is discussed. The design of these compounds so that …

MATERIALS AND METhODS The S-benzoyl protected mercaptoacetyltriglycine (Bz MAG3)
was labeledaccordingto the manufacturersinstruc tions. Forty to sixty mCi of pertechnetatein …

Owing to its optimal nuclear properties, ready availability, low cost and favourable dosimetry,
99mTc continues to be the ideal radioisotope for medical‐imaging applications. Bifunctional …