Brain fuel metabolism, aging, and Alzheimer's disease

S Cunnane, S Nugent, M Roy, A Courchesne-Loyer… - Nutrition, 2011 - Elsevier
Lower brain glucose metabolism is present before the onset of clinically measurable
cognitive decline in two groups of people at risk of Alzheimer's disease---carriers of …

Cerebral blood flow, blood volume and oxygen utilization: normal values and effect of age

KL Leenders, D Perani, AA Lammertsma, JD Heather… - Brain, 1990 - academic.oup.com
Regional cerebral blood flow (CBF), oxygen extraction ratio (OER), oxygen utilization
(CMRO2) and blood volume (CBV) were measured in a group of 34 healthy volunteers (age …

Partial volume correction strategies in PET

O Rousset, A Rahmim, A Alavi, H Zaidi - PET clinics, 2007 - Elsevier
In the early days of PET, the partial volume effect (PVE) was identified as a serious factor
affecting image quality and limiting the accuracy of quantitative analysis. Because of the …

Measurement of radiotracer concentration in brain gray matter using positron emission tomography: MRI-based correction for partial volume effects

HW Müller-Gärtner, JM Links… - Journal of Cerebral …, 1992 - journals.sagepub.com
Accuracy in in vivo quantitation of brain function with positron emission tomography (PET)
has often been limited by partial volume effects. This limitation becomes prominent in …

Quantitative NMR measurements of hippocampal atrophy in Alzheimer's disease

JP Seab, WJ Jagust, STS Wong… - Magnetic resonance …, 1988 - Wiley Online Library
Nuclear magnetic resonance (NMR) imaging was employed to study 10 patients with
Alzheimer's disease (AD) and seven healthy elderly control subjects. Coronal sections were …

Regional glucose metabolic abnormalities are not the result of atrophy in Alzheimer's disease

V Ibáñez, P Pietrini, GE Alexander, ML Furey… - Neurology, 1998 - AAN Enterprises
Objective To determine whether the hypometabolism observed in PET images of patients
with Alzheimer's disease (AD) is due entirely to brain atrophy. Background Reduced brain …

Cortical and subcortical glucose consumption measured by PET in patients with Huntington's disease

T Kuwert, HW Lange, KJ LANGEN, H Herzog, A Aulich… - Brain, 1990 - academic.oup.com
In 23 patients with moderate to severe Huntington's disease (HD) and 21 normal volunteers,
the regional cerebral metabolic rate of glucose consumption (rCMRGlc) was measured in …

Rapid assessment of regional cerebral metabolic abnormalities in single subjects with quantitative and nonquantitative [18F] FDG PET: a clinical validation of …

M Signorini, E Paulesu, K Friston, D Perani… - Neuroimage, 1999 - Elsevier
The [18F] fluorodeoxyglucose ([18F] FDG) method for measuring brain metabolism has not
the wide clinical application that one might expect, partly because of its high cost and the …

Quantitative nuclear medicine imaging using advanced image reconstruction and radiomics

S Ashrafinia - 2019 - search.proquest.com
Our aim is to help put nuclear medicine at the forefront of quantitation on the path to the
realization of personalized medicine. We propose and evaluate (Part I) advanced image …

Integrated software for the analysis of brain PET/SPECT studies with partial-volume-effect correction

M Quarantelli, K Berkouk, A Prinster… - Journal of Nuclear …, 2004 - Soc Nuclear Med
We present software for integrated analysis of brain PET studies and coregistered
segmented MRI that couples a module for automated placement of regions of interest (ROI) …