The detailed investigation of regional differences in lung function at a local level began
when suitable gamma-ray emitting isotopes and focused external radiation detectors …

The in vivo regional distribution of pulmonary beta-adrenoceptors was imaged and
quantified in humans with the hydrophilic beta-adrenoceptor antagonist (S)-CGP-12177 …

The rapid emergence of new imaging modalities like positron emission tomography (PET)
and single photon emission computerized tomography (SPECT) and their advance into the …

Recent advances in the efficient production of high purity radioiodine (123 I) and new
efficient radiolabeling techniques have allowed the development of new classes of …

Abstract Although 125 I-hydroxypindolol (125 I-HYP) has been an excellent probe of
adenoceptor function in certain tissues, but 125 I-pindolol (125 I-PIN) was found more …

Alterations in cardiac autonomic neuronal function have become the focus of intense
research in various cardiovascular diseases. Both single-photon emission tomography …

Cardiac sympathetic neuronal function is closely coupled with β-adrenoceptors and
adrenergic signaling. However, the recovery process of sympathetic neuronal function and β …

As is well documented in other chapters of this book, beta-adrenergic receptors play an
important role in modulating a variety of target cell responses to catecholamines …

MATERIALSAND METHODS Iodine-125-labeled 4-iododexetimide (4-['251] iododexetim
ide) and 4-iodolevetimide (4-['25I] iodolevetimide) were syn 4-[1251] iododexetimidebinding …

Abstract Changes in receptor populations may be early markers of disease, or indicators of
the therapeutic success. A large research effort is therefore directed towards tomographic …