Monoclonal antibodies (mAbs) are currently the largest and most dominant class of
therapeutic proteins. Inter-individual variability has been observed for several mAbs; …

Rational in vivo application of monoclonal antibodies for diagnosis and therapy of cancer
requires an understanding of both the global and microscopic pharmacology of …

Methodsfor elucidatingthe mechanismsby whichradiolabeledanthodiesaretakenup and
accumulated intumor and liverare reviewed. These indude the use of isolated perfused rat …

This review describes the knowledge to date in the use of antibodies and antibody-based
derivatives for targeting effector molecules or cytotoxic drugs to selected cells in the body …

A human B-cell lymphoma xenograft model was used to test whether the administration of
unlabeled MoAb prior to injection of radiolabeled monoclonal antibody (MoAb) improves …

Just as Kierkegaarde observed that," life must be understood backward [but]... lived
forward"(1), so it is with science, which must be performed forward--but may be written …

Hybrid molecules prepared by linking toxins to monoclonal antibodies (MAbs) are cytotoxic
to cells bearing the target antigen. The toxin most widely used has been the plant toxin ricin …

The aim of this study was to examine factors that may influence the pharmacokinetics,
diagnostic accuracy, and dosimetry in radioimmunodetection and radioimmunotherapy with …

While monoclonal antibodies have solved many of the difficulties of using immunologic
reagents for radioimmunodiagnosis and therapy, in the 13 years since their introduction a …

Objective: Determine the role of phagocytosis in the deposition of acute phase SAA protein
in peripheral organs as AA amyloid. Methods: AA amyloidosis was induced by injection of …