Radiohalogenation of proteins: an overview of radionuclides, labeling methods and reagents for conjugate labeling
DS Wilbur - Bioconjugate chemistry, 1992 - ACS Publications
434 Bioconjugate Chem., Vol. 3, No. 6, 1992 Wilbur easy to use and readily available at a
nominal cost from commercial sources. Other radionuclides of the halogen group, while not …
nominal cost from commercial sources. Other radionuclides of the halogen group, while not …
Radioimmunodetection and radioimmunotherapy
SM Larson, JA Carrasquillo, JC Reynolds - Cancer investigation, 1984 - Taylor & Francis
The development of monoclonal antibodies which recognize human “tumor-associated
antigens” has had broad implications for tumor immunology. Of principal importance is the …
antigens” has had broad implications for tumor immunology. Of principal importance is the …
[PDF][PDF] Imaging and treatment of B-cell lymphoma
JF Eary, OW Press, CC Badger… - Journal of Nuclear …, 1990 - Soc Nuclear Med
No. of patientsLymphoma typeTumor mass (9) 5FoIlicular small-cleavedcell75— 2710
g3Diffuse, small-cleavedcell200-2300 g2Follicular mixed60— 3009 with normal human …
g3Diffuse, small-cleavedcell200-2300 g2Follicular mixed60— 3009 with normal human …
Prevention of radiolysis of monoclonal antibody during labeling
MC Chakrabarti, N Le, CH Paik… - The Journal of …, 1996 - search.proquest.com
17. Khawli LA. Kassis Al. m-['*']lodoaniline: a useful reagent for radiolabeling biotin. Page 1
15. Rosebrough SP. Plasma stability and pharmacokinetics of radiolabeled deferoxaminebiotin …
15. Rosebrough SP. Plasma stability and pharmacokinetics of radiolabeled deferoxaminebiotin …
Impact of the high tyrosine fraction in complementarity determining regions: measured and predicted effects of radioiodination on IgG immunoreactivity
TK Nikula, M Bocchia, MJ Curcio, G Sgouros, Y Ma… - Molecular …, 1995 - Elsevier
Although iodine-131 is the most widely used radionuclide for radioimmunotherapy, direct
radiolabeling methods yield decreased immunoreactivity of the antibody as a function of …
radiolabeling methods yield decreased immunoreactivity of the antibody as a function of …
Optimal quality 131I-monoclonal antibodies on high-dose labeling in a large reaction volume and temporarily coating the antibody with IODO-GEN
GW Visser, RP Klok, JWK Gebbinck… - Journal of Nuclear …, 2001 - Soc Nuclear Med
A novel, facile procedure for efficient coupling of high doses of 131I to monoclonal
antibodies (MAbs) was developed with minimal chemical and radiation damage. Methods …
antibodies (MAbs) was developed with minimal chemical and radiation damage. Methods …
Delivery of melanoma-associated immunoglobulin monoclonal antibody and Fab fragments to normal brain utilizing osmotic blood-brain barrier disruption
EA Neuwelt, PA Barnett, I Hellström, KE Hellström… - Cancer research, 1988 - AACR
Abstract Iodinated monoclonal antibodies (IgG 96.5 and two monomeric Fab fragments 96.5
and 48.7) to melanoma-associated antigens were administered after osmotic blood-brain …
and 48.7) to melanoma-associated antigens were administered after osmotic blood-brain …
Tumor Targeting of 211At-Labeled Antibody under Sodium Ascorbate Protection against Radiolysis
H Takashima, K Ohnuki, S Manabe, Y Koga… - Molecular …, 2022 - ACS Publications
Astatine-211 (211At) is an alpha emitter applicable to radioimmunotherapy (RIT), a cancer
treatment that utilizes radioactive antibodies to target tumors. In the preparation of 211At …
treatment that utilizes radioactive antibodies to target tumors. In the preparation of 211At …
Use of I-131 labeled, murine Fab against a high molecular weight antigen of human melanoma: preliminary experience.
SM Larson, JA Carrasquillo, RW McGuffin, KA Krohn… - Radiology, 1985 - pubs.rsna.org
High molecular weight antigen (HMWA) is a tumor-associated proteoglycan of human
malignant melanoma. I-131 labeled Fab fragments of these specific antibodies were used …
malignant melanoma. I-131 labeled Fab fragments of these specific antibodies were used …
Chloramine-T in high-specific-activity radioiodination of antibodies using N-succinimidyl-3-(trimethylstannyl) benzoate as an intermediate
S Lindegren, G Skarnemark, L Jacobsson… - Nuclear medicine and …, 1998 - Elsevier
Monoclonal antibodies C215 and MOv18 have been radiohalogenated, using a single-batch
method employing N-succinimidyl-3-(trimethylstannyl) benzoate, m-MeATE. Labelling to the …
method employing N-succinimidyl-3-(trimethylstannyl) benzoate, m-MeATE. Labelling to the …