Quantitative whole-body autoradiography: past, present and future

A McEwen, C Henson - Bioanalysis, 2015 - Future Science
Traditional bioanalytical measurements determine concentrations of drug and metabolites in
plasma; however, most drugs exert their effects in defined target tissues. As there is no clear …

Alterations in L-glutamate binding in Alzheimer's and Huntington's diseases

JT Greenamyre, JB Penney, AB Young, CJ D'Amato… - Science, 1985 - science.org
Brain sections from patients who had died with senile dementia of the Alzheimer's type
(SDAT), Huntington's disease (HD), or no neurologic disease were studied by …

Autoradiography: high-resolution molecular imaging in pharmaceutical discovery and development

EG Solon - Expert opinion on drug discovery, 2007 - Taylor & Francis
Autoradiography (ARG) is a powerful, high resolution, quantitative molecular imaging
technique used to study the tissue distribution of radiolabeled xenobiotics in biologic …

Regional myocardial substrate uptake in hypertensive rats: a quantitative autoradiographic measurement

Y Yonekura, AB Brill, P Som, K Yamamoto… - Science, 1985 - science.org
Severe hypertension causes global and regional changes in myocardial perfusion and
substrate utilization. Regional perfusion and fatty acid utilization were evaluated by dual …

Double-labeled metabolic maps of memory

ER John, Y Tang, AB Brill, R Young, K Ono - Science, 1986 - science.org
The physical changes representing a memory are believed to be localized to specific
neurons, widely distributed in multiple parallel pathways in the brain. 2-Fluorodeoxyglucose …

The development and in-vivo behavior of tin containing radiopharmaceuticals—II. Autoradiographic and scintigraphic studies in normal animals and in animal models …

ZH Oster, P Som, SC Srivastava, RG Fairchild… - International Journal of …, 1985 - Elsevier
Abstract Various 117m Sn (2+ and 4+) compounds in well defined oxidation states were
studied in normal mice using whole body autoradiography (WBARG), tissue distribution and …

Brown adipose tissue and nuclear medicine imaging

WA Weber - Journal of Nuclear Medicine, 2004 - Soc Nuclear Med
During the last 2 years, brown adipose tissue (BAT) has received considerable attention in
the field of nuclear medicine. BAT has been shown to accumulate 18F-FDG (1–4) …

Radionuclide targeting and dosimetry at the microscopic level: the role of microautoradiography

MRB Puncher, PJ Blower - European journal of nuclear medicine, 1994 - Springer
The understanding of localisation mechanisms and microdosimetry of diagnostic and
therapeutic radiopharmaceuticals depends on knowledge of their biodistribution at the …

Development of a high-resolution alpha camera

S Yamamoto, T Iida, I Kanno - Nuclear Instruments and Methods in Physics …, 1997 - Elsevier
We have developed and tested a high-resolution alpha camera. The alpha camera consists
of a thin CaF2 (Eu) scintillator, a tapered fiber optics plate (tapered fiber), a position …

Positron emission tomography/computed tomography fusion imaging in brown adipose tissue

AJ Minotti, L Shah, K Keller - Clinical nuclear medicine, 2004 - journals.lww.com
Fluorine-18 fluoro deoxyglucose positron emission tomography (F-18 FDG PET) imaging is
an exciting modality for the study of pathophysiology. The fusion of computed tomography …