Bone as an effect compartment: models for uptake and release of drugs
D Stepensky, L Kleinberg, A Hoffman - Clinical pharmacokinetics, 2003 - Springer
Abstract 'Bone-seeking agents' are drugs characterised by high affinity for bone, and are
disposed in bone for prolonged periods of time while maintaining remarkably low systemic …
disposed in bone for prolonged periods of time while maintaining remarkably low systemic …
Preoperative 99mTc-MDP scintimetry of femoral neck fractures
S Holmberg, KG Thorngren - Acta Orthopaedica Scandinavica, 1984 - Taylor & Francis
Preoperative 99mTc-MDP-scintimetry was performed in 117 patients with femoral neck
fractures. Scintimetry was shown to be superior to visual evaluation. The ratio was …
fractures. Scintimetry was shown to be superior to visual evaluation. The ratio was …
Quantitative regional blood-flow analysis and its clinical application during routine bone-scanning.
SD Deutsch, EJ Gandsman, SC Spraragen - JBJS, 1981 - journals.lww.com
A method of combined dynamic and static bone-imaging using technetium 99-labeled
phosphonate is described. During the dynamic part of the study, immediately after …
phosphonate is described. During the dynamic part of the study, immediately after …
Radionucleide imaging in pharmaceutical, physiological and pharmacological research
JG Hardy, CG Wilson - Clinical Physics and Physiological …, 1981 - iopscience.iop.org
TO be effective a drug must reach its site of action in amounts sufficient to exert a therapeutic
effect. The dose-response relationship for the drug is affected by many factors including the …
effect. The dose-response relationship for the drug is affected by many factors including the …
A study of irradiated bone. Part II. changes in Tc-99m pyrophosphate bone imaging.
MA King, DA Weber, GW Casarett… - Journal of Nuclear …, 1980 - europepmc.org
Quantitative Tc-99m pyrophosphate bone imaging was carried out in locally irradiated and
control areas of New Zealand albino rabbits to determine the potential role of bone imaging …
control areas of New Zealand albino rabbits to determine the potential role of bone imaging …
The short-term fixation of radiopharmaceuticals in bone
C Schümichen, H Rempfle, M Wagner… - European Journal of …, 1979 - Springer
The relationship between local blood flow and bone clearance of 18 F, 32 PP
(orthophosphate), 32 P-PP i (pyrophosphate), 45 Ca, 85 Sr, 99mTc-and 113 Sn-EHDP was …
(orthophosphate), 32 P-PP i (pyrophosphate), 45 Ca, 85 Sr, 99mTc-and 113 Sn-EHDP was …
Relationship of 99mTc-MDP uptake to regional osseous circulation in skeletally immature and mature dogs
P McKinstry, JE Schnitzer, TR Light, JA Ogden… - Skeletal Radiology, 1982 - Springer
Uptake of intravenously injected 99m Tc-MDP in multiple regions of healthy skeletally
immature and mature dogs was correlated with regional chondro-osseous blood flow …
immature and mature dogs was correlated with regional chondro-osseous blood flow …
The use of bone scanning for the diagnosis and management of musculoskeletal trauma
SD Deutsch, EJ Gandsman - Surgical Clinics of North America, 1983 - Elsevier
Bone scanning provides a unique way of monitoring early metabolic changes in bone and
its adjacent soft tissues after trauma. Dynamic imaging along with static imaging can be …
its adjacent soft tissues after trauma. Dynamic imaging along with static imaging can be …
Bone scintigraphy in Paget's disease treated with combined calcitonin and diphosphonate (EHDP)
C Vellenga, EKJ Pauwels, OLM Bijvoet… - Metabolic Bone Disease …, 1982 - Elsevier
Bone scintigraphic results for 28 patients with Paget's disease treated with a combination of
EHDP and calcitonin are reported. The uptake of the bone scintigraphic agent decreased …
EHDP and calcitonin are reported. The uptake of the bone scintigraphic agent decreased …
Scintigraphic aspects of the recurrence of treated Paget's disease of bone.
CJ Vellenga, EK Pauwels, OL Bijvoet… - Journal of Nuclear …, 1981 - europepmc.org
The value of bone scintigraphy in the prediction and detection of a relapse of Paget's
disease of bone after treatment, as well as the pattern of such a recurrence, were studied in …
disease of bone after treatment, as well as the pattern of such a recurrence, were studied in …