Radiolabeled somatostatin receptor antagonists are preferable to agonists for in vivo peptide receptor targeting of tumors

…, B Waser, R Cescato, D Wild, X Wang… - Proceedings of the …, 2006 - National Acad Sciences
Targeting neuroendocrine tumors expressing somatostatin receptor subtypes (sst) with
radiolabeled somatostatin agonists is an established diagnostic and therapeutic approach in …

[HTML][HTML] Near-infrared fluorescence imaging in humans with indocyanine green: a review and update

…, IC Tan, MB Aldrich, KE Adams, X Wang… - Open surgical …, 2010 - ncbi.nlm.nih.gov
Near-infrared (NIR) fluorescence imaging clinical studies have been reported in the literature
with six different devices that employ various doses of indocyanine green (ICG) as a non-…

A safe and potent anti-CD19 CAR T cell therapy

…, S Gao, L Ping, X Wang, N Zhou, J Zhang, Y Wang… - Nature medicine, 2019 - nature.com
Anti-CD19 chimeric antigen receptor (CAR) T cell therapies can cause severe cytokine-release
syndrome (CRS) and neurotoxicity, impeding their therapeutic application. Here we …

Development of a potent DOTA-conjugated bombesin antagonist for targeting GRPr-positive tumours

R Mansi, X Wang, F Forrer, B Waser, R Cescato… - European journal of …, 2011 - Springer
Purpose Radiolabelled somatostatin-based antagonists show a higher uptake in tumour-bearing
mouse models than agonists of similar or even distinctly higher receptor affinity. Very …

Evaluation of a 1, 4, 7, 10-Tetraazacyclododecane-1, 4, 7, 10-Tetraacetic acid–conjugated bombesin-based radioantagonist for the labeling with single-photon …

R Mansi, X Wang, F Forrer, S Kneifel, ML Tamma… - Clinical cancer …, 2009 - AACR
Purpose: G protein–coupled receptor agonists are being used as radiolabeled vectors for in
vivo localization and therapy of tumors. Recently, somatostatin-based antagonists were …

Metallophilic interaction-mediated hierarchical assembly and temporal-controlled dynamic chirality inversion of metal–organic supramolecular polymers

L Yao, K Fu, X Wang, M He, W Zhang, PY Liu, YP He… - ACS …, 2023 - ACS Publications
The study of dynamic supramolecular chirality inversion (SMCI) not only helps to deepen the
understanding of chiral transfer and amplification in both living organizations and artificially …

Macrocyclic chelator-coupled gastrin-based radiopharmaceuticals for targeting of gastrin receptor-expressing tumours

S Good, MA Walter, B Waser, X Wang… - European journal of …, 2008 - Springer
Purpose Diethylenetriamine-pentaacetic acid (DTPA)-coupled minigastrins are unsuitable
for therapeutic application with the available β-emitting radiometals due to low complex …

Detecting fibroblast activation proteins in lymphoma using 68Ga-FAPI PET/CT

X Jin, M Wei, S Wang, G Wang, Y Lai… - Journal of Nuclear …, 2022 - Soc Nuclear Med
Cancer-associated fibroblasts that overexpress fibroblast activation protein (FAP) are enriched
in many epithelial carcinomas and in hematologic neoplasms. PET/CT with radiolabeled …

Structural insight into precursor tRNA processing by yeast ribonuclease P

…, M Tan, Y Zhang, S Niu, J Chen, S Shi, S Qiu, X Wang… - Science, 2018 - science.org
INTRODUCTION Ribonuclease P (RNase P), a universal ribozyme that has been found in
organisms from all three domains of life, processes the 5′ end of transfer RNA (tRNA). …

[HTML][HTML] Redefining the modular organization of the core Mediator complex

X Wang, Q Sun, Z Ding, J Ji, J Wang, X Kong, J Yang… - Cell research, 2014 - nature.com
The Mediator complex plays an essential role in the regulation of eukaryotic transcription.
The Saccharomyces cerevisiae core Mediator comprises 21 subunits, which are organized …