Conventional antibody–drug conjugates (ADCs) are heterogeneous mixtures of chemically
distinct molecules that vary in both drugs/antibody (DAR) and conjugation sites. Suboptimal …

CD98 is expressed on several tissue types and specifically upregulated on fast‐cycling cells
undergoing clonal expansion. Various solid (eg., nonsmall cell lung carcinoma) as well as …

Purpose We recently developed a cysteine-containing peptide tag (C-tag) that allows for site-specific
modification of C-tag-containing fusion proteins with a bifunctional chelator, HYNIC …

Labeled annexin V is widely used to detect cell death in vitro and in vivo. Nearly all studies
have been done with annexin V derivatized via amine-directed bifunctional agents; it was …

Objective— Mural inflammation and neovascularization are characteristic pathological features
of abdominal aortic aneurysm (AAA) disease. Vascular endothelial growth factor receptor …

The primary function of tissue factor (TF) resides in the vasculature as a cofactor of blood
clotting; however, multiple solid tumors aberrantly express this transmembrane receptor on the …

Soft tissue sarcoma (STS) is a heterogenous tumor arising from the embryonic mesoderm
represented by approximately 50 histological subtypes. Effective therapeutic intervention is …

Vascular endothelial growth factor (VEGF) and its receptors (VEGFRs) drive angiogenesis,
and several VEGFR inhibitors are already approved for use as single agents or in …

Angiogenesis is a fundamental feature of tumor development, and therefore, the tracers for
molecular imaging of specific angiogenic biomarkers are expected to be useful for diagnostics…

Several drugs targeting vascular endothelial growth factor (VEGF) and its receptors (VEGFRs)
are approved for cancer treatment. However, these drugs induce relatively modest and …