Safety and efficacy of pembrolizumab monotherapy in patients with previously treated advanced gastric and gastroesophageal junction cancer: phase 2 clinical …
Importance Therapeutic options are needed for patients with advanced gastric cancer whose
disease has progressed after 2 or more lines of therapy. Objective To evaluate the safety …
disease has progressed after 2 or more lines of therapy. Objective To evaluate the safety …
[HTML][HTML] Safety and efficacy of durvalumab (MEDI4736), an anti–programmed cell death ligand-1 immune checkpoint inhibitor, in patients with advanced urothelial …
…, S Sharma, S Rafii, ZA Wainberg… - Journal of Clinical …, 2016 - ncbi.nlm.nih.gov
Purpose To investigate the safety and efficacy of durvalumab, a human monoclonal antibody
that binds programmed cell death ligand-1 (PD-L1), and the role of PD-L1 expression on …
that binds programmed cell death ligand-1 (PD-L1), and the role of PD-L1 expression on …
[HTML][HTML] Dabrafenib and trametinib treatment in patients with locally advanced or metastatic BRAF V600–mutant anaplastic thyroid cancer
V Subbiah, RJ Kreitman, ZA Wainberg… - Journal of Clinical …, 2018 - ncbi.nlm.nih.gov
Purpose We report the efficacy and safety of dabrafenib (BRAF inhibitor) and trametinib (MEK
inhibitor) combination therapy in BRAF V600E–mutated anaplastic thyroid cancer, a rare, …
inhibitor) combination therapy in BRAF V600E–mutated anaplastic thyroid cancer, a rare, …
Efficacy and safety of pembrolizumab or pembrolizumab plus chemotherapy vs chemotherapy alone for patients with first-line, advanced gastric cancer: the KEYNOTE …
…, A Benson, J Chao, AH Ko, ZA Wainberg… - JAMA …, 2020 - jamanetwork.com
… Wainberg, MD 25 ; Uma Kher, MS 26 ; Sukrut Shah, PhD 26 ; S. Peter Kang, MD 26 ; Josep
… Dr Wainberg reported grants from Novartis and Plexxikon and personal fees from Merck, …
… Dr Wainberg reported grants from Novartis and Plexxikon and personal fees from Merck, …
[HTML][HTML] Sotigalimab and/or nivolumab with chemotherapy in first-line metastatic pancreatic cancer: clinical and immunologic analyses from the randomized phase 2 …
…, MH O'Hara, EM O'Reilly, RA Wolff, ZA Wainberg… - Nature medicine, 2022 - nature.com
Chemotherapy combined with immunotherapy has improved the treatment of certain solid
tumors, but effective regimens remain elusive for pancreatic ductal adenocarcinoma (PDAC). …
tumors, but effective regimens remain elusive for pancreatic ductal adenocarcinoma (PDAC). …
[HTML][HTML] Dabrafenib plus trametinib in BRAFV600E-mutated rare cancers: the phase 2 ROAR trial
V Subbiah, RJ Kreitman, ZA Wainberg, A Gazzah… - Nature medicine, 2023 - nature.com
BRAFV600E alterations are prevalent across multiple tumors. Here we present final efficacy
and safety results of a phase 2 basket trial of dabrafenib (BRAF kinase inhibitor) plus …
and safety results of a phase 2 basket trial of dabrafenib (BRAF kinase inhibitor) plus …
[HTML][HTML] Structure-guided blockade of CSF1R kinase in tenosynovial giant-cell tumor
WD Tap, ZA Wainberg, SP Anthony… - … England Journal of …, 2015 - Mass Medical Soc
Background Expression of the colony-stimulating factor 1 (CSF1) gene is elevated in most
tenosynovial giant-cell tumors. This observation has led to the discovery and clinical …
tenosynovial giant-cell tumors. This observation has led to the discovery and clinical …
Lapatinib in combination with capecitabine plus oxaliplatin in human epidermal growth factor receptor 2–positive advanced or metastatic gastric, esophageal, or …
…, P Salman, J Li, SA Protsenko, ZA Wainberg… - Journal of Clinical …, 2016 - ascopubs.org
Purpose To evaluate the efficacy of adding lapatinib to capecitabine and oxaliplatin (CapeOx)
in patients with previously untreated human epidermal growth factor receptor 2 (HER2) –…
in patients with previously untreated human epidermal growth factor receptor 2 (HER2) –…
Assessment of pembrolizumab therapy for the treatment of microsatellite instability–high gastric or gastroesophageal junction cancer among patients in the KEYNOTE …
…, CS Shih, S Shah, P Bhagia, ZA Wainberg - JAMA …, 2021 - jamanetwork.com
Importance Immunotherapy has been associated with improved outcomes among patients
who have received previous treatment for microsatellite instability–high (MSI-H) tumors. …
who have received previous treatment for microsatellite instability–high (MSI-H) tumors. …
Evaluation of BGJ398, a fibroblast growth factor receptor 1-3 kinase inhibitor, in patients with advanced solid tumors harboring genetic alterations in fibroblast growth …
…, GG Tian, M Campone, ZA Wainberg… - Journal of Clinical …, 2017 - ascopubs.org
Purpose This two-part, first-in-human study was initiated in patients with advanced solid
tumors harboring genetic alterations in fibroblast growth factor receptors (FGFRs) to determine …
tumors harboring genetic alterations in fibroblast growth factor receptors (FGFRs) to determine …