Radiolabeled fluoromisonidazole has been characterized as a probe for hypoxic cells in
vitro and in vivo. The uptake and retention of $[{}^{3}{\rm H}]\text{fluoromisonidazole}$ and $[{}^{…

Fluoromisonidazole labeled with H-3 or F-18 has been tested as a quantitative probe for
hypoxic cells in vitro and in rodent and spontaneous dog tumors in vivo. In V-79, EMT-6(UW), …

We studied the tumor uptake of [ 67 Ga]citrate, [ 59 Fe]citrate, and 125 I-labeled transferrin (TF)
by the in vitro growth form of EMT-6, a sarcoma-like mammary tumor of BALB/c mice. In …

Radiolabeled fluoromisonidazole (FMISO) is being investigated as an imaging agent for
hypoxia in tumors and nonmalignant tissues in myocardial infarct or stroke. In this study in vitro …

An investigation of the Moorish ornaments from the Alhambra (in Granada, Spain) shows
that their symmetry groups belong to 13 different crystallographic (wallpaper) classes; this …

Misonidazole is a known hypoxic cell sensitizer that binds covalently in hypoxic cells. Its
congenerslabeledwith 77Br, 75Br, or 18F, are likelycandidatesfor imaginghypoxia. We have …

[ 18 F]Fluoromisonidazole (1-(3-[ 18 F]fluoro-2-hydroxypropyl)-2-nitroimidazole, [ 18 F]FMISO)
is a nitroimidazole compound that is being used as a new imaging agent for hypoxia. …

The 2-nitroimidazolefluoromisonidazoleis metabolicallytrappedin viablehypoxiccellsin inverse
proportion to P02. This attribute suggests that [18F] fluoromisonidazolemay be useful for …

Uptake of [3H] 2-deoxyglucose was studied in BALB/c mice with EMT-6 sarcoma, in Buffalo
rats with Morris 7777 hepatoma, and in eight dogs with spontaneous neoplasms: five …

MATERIALS AND METHODS A colony of inbred AKR mice from commercial breeders* is
maintained at our research center. For the tumor studies, mice were held until signs of …