Molecular and cellular effects of radiotherapy on tumor microenvironment (TME) can help
prime and propagate antitumor immunity. We hypothesized that delivering radiation to all …

Natural killer (NK) cells play a major role in cancer immunotherapies that involve tumor-antigen
targeting by monoclonal antibodies (mAbs). NK cells express a variety of activating and …

Neoantigens induced by random mutations and specific to an individual's cancer are the
most important tumor antigens recognized by T cells. Among immunologically “cold” tumors, …

The distinctive anatomy of the crocodylian skull is intimately linked with dietary ecology,
resulting in repeated convergence on blunt- and slender-snouted ecomorphs. These …

Soft tissue sarcomas (STS) are rare solid tumors of mesenchymal cell origin that display a
heterogenous mix of clinical and pathologic characteristics. STS can develop from fat, muscle, …

Recent evidence indicates that ionizing radiation can enhance immune responses to tumors.
Advances in radiation delivery techniques allow hypofractionated delivery of conformal …

The development of immunotherapy in oncology builds upon many years of scientific
investigation into the cellular mechanics underlying interactions between tumor cells and immune …

Interest in combining radiotherapy and immune checkpoint therapy is growing rapidly. In
this study, we explored a novel combination of this type to augment antitumor immune …

Radiation therapy (RT) activates an in situ vaccine effect when combined with immune checkpoint
blockade (ICB), yet this effect may be limited because RT does not fully optimize tumor …

The avian beak is a key evolutionary innovation whose flexibility has permitted birds to
diversify into a range of disparate ecological niches. We approached the problem of the …