Heritable variation in complex traits is generally considered to be conferred by common
DNA sequence polymorphisms. We tested whether rare DNA sequence variants collectively …

Atherosclerosis is the primary cause of cardiovascular disease, and the risk for atherosclerosis
is inversely proportional to circulating levels of high-density lipoprotein (HDL) cholesterol. …

The lipid droplet (LD) is the major site of cholesterol storage in macrophage foam cells and
is a potential therapeutic target for the treatment of atherosclerosis. Cholesterol, stored as …

PLASMA high density lipoproteins (HDL) are a negative risk factor for atherosclerosis.
Increased HDL is sometimes clustered in families, but a genetic basis has never been clearly …

The inverse relationship between high density lipoprotein (HDL) plasma levels and
coronary heart disease has been attributed to the role that HDL and its major constituent, …

Vascular disease risk is inversely related to circulating levels of high-density lipoprotein (HDL)
cholesterol. However, the mechanisms by which HDL provides vascular protection are …

Mycobacterium tuberculosis (Mtb) survives in macrophages by evading delivery to the
lysosome and promoting the accumulation of lipid bodies, which serve as a bacterial source of …

Cholesterol efflux from macrophages is the first and potentially most important step in
reverse cholesterol transport, a process especially relevant to atherosclerosis and to the …

The binding of HDL to scavenger receptor–BI (SR-BI) mediates cholesterol movement. HDL
also induces multiple cellular signals, which in endothelium occur through SR-BI and …

We compared the effect of lipid composition and particle size of triglyceride-rich low density
lipoprotein (LDL) upon apoprotein B conformation and binding to the LDL receptor. Three …