Direct comparison of liposomal doxorubicin with or without polyethylene glycol coating in C-26 tumor-bearing mice: is surface coating with polyethylene glycol …
RL Hong, CJ Huang, YL Tseng, VF Pang, ST Chen… - Clinical Cancer …, 1999 - AACR
Sterically stabilized liposome is characterized by a surface coating of polyethylene glycol (PEG)
or other polymers that can reduce opsonization of the liposome by plasma proteins. It …
or other polymers that can reduce opsonization of the liposome by plasma proteins. It …
Translocation of liposomes into cancer cells by cell-penetrating peptides penetratin and tat: a kinetic and efficacy study
YL Tseng, JJ Liu, RL Hong - Molecular pharmacology, 2002 - ASPET
Unlike conventional liposomes, sterically stabilized liposomes, with their smaller volume of
distribution and reduced clearance, preferentially convey encapsulated drugs into tumor sites…
distribution and reduced clearance, preferentially convey encapsulated drugs into tumor sites…
Phase I and pharmacokinetic study of a stable, polyethylene‐glycolated liposomal doxorubicin in patients with solid tumors: The relation between pharmacokinetic …
RL Hong, YL Tseng - … Journal of the American Cancer Society, 2001 - Wiley Online Library
BACKGROUND Compared with free drug, sterically stabilized liposomal drug has prolonged
circulation time and, thereby, higher tumor selectivity and antitumor activity. The stability in …
circulation time and, thereby, higher tumor selectivity and antitumor activity. The stability in …
A novel peptide specifically binding to nasopharyngeal carcinoma for targeted drug delivery
TY Lee, HC Wu, YL Tseng, CT Lin - Cancer research, 2004 - AACR
Nasopharyngeal carcinoma (NPC) is a common cancer among Chinese living in southern
China, Taiwan, and Singapore. The 5-year survival rate in the early stage of NPC has been …
China, Taiwan, and Singapore. The 5-year survival rate in the early stage of NPC has been …
Improved pharmacokinetics and efficacy of a highly stable nanoliposomal vinorelbine
…, Z Guo, ME Hayes, JW Park, CJ Ou, YL Tseng… - Journal of pharmacology …, 2009 - ASPET
Effective liposomal formulations of vinorelbine (5′ nor-anhydro-vinblastine; VRL) have been
elusive due to vinorelbine's hydrophobic structure and resulting difficulty in stabilizing the …
elusive due to vinorelbine's hydrophobic structure and resulting difficulty in stabilizing the …
Improvement of biodistribution and therapeutic index via increase of polyethylene glycol on drug-carrying liposomes in an HT-29/luc xenografted mouse model
Liposomes modified with a high concentration of polyethylene glycol (PEG) could significantly
prolong the retention time of the carried drug in the circulation, thus improving the drug …
prolong the retention time of the carried drug in the circulation, thus improving the drug …
One-step mixing with humanized anti-mPEG bispecific antibody enhances tumor accumulation and therapeutic efficacy of mPEGylated nanoparticles
…, CH Chuang, TC Cheng, YC Hsieh, Y Tseng… - Biomaterials, 2014 - Elsevier
Methoxy PEGylated nanoparticles (mPEG-NPs) are increasingly used for cancer imaging
and therapy. Here we describe a general and simple approach to confer tumor tropism to any …
and therapy. Here we describe a general and simple approach to confer tumor tropism to any …
Simple and efficient liposomal encapsulation of topotecan by ammonium sulfate gradient: stability, pharmacokinetic and therapeutic evaluation
…, WF Cheng, K Hong, FH Chang, YL Tseng - Anti-cancer …, 2002 - journals.lww.com
Topotecan (TPT), a topoisomerase I inhibitor, is presently undergoing clinical evaluation
worldwide. Previous studies have shown that entrapping TPT within multi-lamellar vesicle …
worldwide. Previous studies have shown that entrapping TPT within multi-lamellar vesicle …
Diagnostic and therapeutic evaluation of 111In-vinorelbine-liposomes in a human colorectal carcinoma HT-29/luc-bearing animal model
Colorectal carcinoma is a highly prevalent and common cause of cancer in Taiwan. There is
still no available cure for this malignant disease. To address this issue, we applied the …
still no available cure for this malignant disease. To address this issue, we applied the …
Therapeutic efficacy evaluation of 111In-labeled PEGylated liposomal vinorelbine in murine colon carcinoma with multimodalities of molecular imaging
In our previous studies using combined radioisotopes with chemotherapeutic liposomal
drugs (ie, 111 In-labeled polyethylene glycol (PEG)ylated liposomal vinorelbine) we have …
drugs (ie, 111 In-labeled polyethylene glycol (PEG)ylated liposomal vinorelbine) we have …