Enhancers, critical determinants of cellular identity, are commonly recognized by correlative
chromatin marks and gain-of-function potential, although only loss-of-function studies can …

This study assessed the effectiveness of autologous bone marrow stromal cell
transplantation for the repair of full-thickness articular cartilage defects in the patellae of a 26-year-old …

Transfusion of red blood cells (RBCs) is a standard and indispensable therapy in current
clinical practice. In vitro production of RBCs offers a potential means to overcome a shortage of …

Long non-coding RNAs (lncRNAs) are largely heterogeneous and functionally uncharacterized.
Here, using FANTOM5 cap analysis of gene expression (CAGE) data, we integrate …

The freshwater cnidarian Hydra was first described in 1702 1 and has been the object of
study for 300 years. Experimental studies of Hydra between 1736 and 1744 culminated in the …

Continuous cell lines consist of cultured cells derived from a specific donor and tissue of
origin that have acquired the ability to proliferate indefinitely. These cell lines are well‐…

Rel/NF-κB transcription factors have been implicated in regulating a wide variety of genes
important in cellular processes that include cell division, cell survival, differentiation and …

Fetal hemoglobin (HbF, α 2 γ 2 ) level is genetically controlled and modifies severity of adult
hemoglobin (HbA, α 2 β 2 ) disorders, sickle cell disease, and β-thalassemia. Common …

Disorders resulting from mutations in the hemoglobin subunit beta gene (HBB; which
encodes β-globin), mainly sickle cell disease (SCD) and β-thalassemia, become symptomatic …

Multipotent self-renewing haematopoietic stem cells (HSCs) regenerate the adult blood
system after transplantation 1 , which is a curative therapy for numerous diseases including …