Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity

…, Y Ohmoto, T Funahashi, Y Matsuzawa - Biochemical and …, 1999 - Elsevier
We isolated the human adipose-specific and most abundant gene transcript, apM1 (Maeda,
K., et al.,Biochem. Biophys. Res. Commun.221, 286–289, 1996). The apM1 gene product …

Gain-of-Function Mutations of c-kit in Human Gastrointestinal Stromal Tumors

…, M Takeda, G Muhammad Tunio, Y Matsuzawa… - Science, 1998 - science.org
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors in the
human digestive tract, but their molecular etiology and cellular origin are unknown. …

Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients

…, S Yamashita, T Hanafusa, Y Matsuzawa - … , and vascular biology, 2000 - Am Heart Assoc
Adiponectin is a novel, adipose-specific protein abundantly present in the circulation, and it
has antiatherogenic properties. We analyzed the plasma adiponectin concentrations in age- …

Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia

…, S Tanaka, K Hotta, Y Matsuzawa… - The Journal of …, 2001 - academic.oup.com
Plasma concentrations of adiponectin, a novel adipose-specific protein with putative
antiatherogenic and antiinflammatory effects, were found to be decreased in Japanese individuals …

Visfatin: a protein secreted by visceral fat that mimics the effects of insulin

…, S Yamanaka, R Hiramatsu, Y Matsuzawa… - Science, 2005 - science.org
Fat tissue produces a variety of secreted proteins (adipocytokines) with important roles in
metabolism. We isolated a newly identified adipocytokine, visfatin, that is highly enriched in the …

Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin

…, S Yamashita, T Funahashi, Y Matsuzawa - Circulation, 1999 - Am Heart Assoc
Background—Among the many adipocyte-derived endocrine factors, we recently found an
adipocyte-specific secretory protein, adiponectin, which was decreased in obesity. Although …

cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (AdiPoseMost abundant Gene transcript 1)

…, I Shimomura, T Funahashi, Y Matsuzawa… - Biochemical and …, 1996 - Elsevier
We isolated a novel adipose-specific gene, apM1, the transcript of which is the most abundant
in the mRNA population from human adipose tissue. Northern blotting revealed that the …

Diet-induced insulin resistance in mice lacking adiponectin/ACRP30

…, S Takeda, T Aoyama, T Funahashi, Y Matsuzawa - Nature medicine, 2002 - nature.com
Here we investigated the biological functions of adiponectin/ACRP30, a fat-derived hormone,
by disrupting the gene that encodes it in mice. Adiponectin/ACRP30-knockout (KO) mice …

Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis

M Yokoyama, H Origasa, M Matsuzaki, Y Matsuzawa… - The lancet, 2007 - thelancet.com
Background Epidemiological and clinical evidence suggests that an increased intake of long-chain
n-3 fatty acids protects against mortality from coronary artery disease. We aimed to …

PPARγ ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein

…, K Hotta, T Nakamura, I Shimomura, Y Matsuzawa - Diabetes, 2001 - Am Diabetes Assoc
Insulin resistance and its dreaded consequence, type 2 diabetes, are major causes of
atherosclerosis. Adiponectin is an adipose-specific plasma protein that possesses anti-…