HIF1α is required for osteoclast activation by estrogen deficiency in postmenopausal osteoporosis
Y Miyauchi, Y Sato, T Kobayashi… - Proceedings of the …, 2013 - National Acad Sciences
In women, estrogen deficiency after menopause frequently accelerates osteoclastic bone
resorption, leading to osteoporosis, the most common skeletal disorder. However, mechanisms …
resorption, leading to osteoporosis, the most common skeletal disorder. However, mechanisms …
Osteoclast stimulatory transmembrane protein and dendritic cell–specific transmembrane protein cooperatively modulate cell–cell fusion to form osteoclasts and …
…, R Iwasaki, T Kobayashi, Y Sato… - Journal of Bone and …, 2012 - academic.oup.com
Cell–cell fusion is a dynamic phenomenon promoting cytoskeletal reorganization and
phenotypic changes. To characterize factors essential for fusion of macrophage lineage cells, we …
phenotypic changes. To characterize factors essential for fusion of macrophage lineage cells, we …
Osteoclasts are dispensable for hematopoietic stem cell maintenance and mobilization
…, M Kawasumi, K Hashimoto, T Kimura, Y Sato… - Journal of Experimental …, 2011 - rupress.org
Hematopoietic stem cells (HSCs) are maintained in a specific bone marrow (BM) niche in
cavities formed by osteoclasts. Osteoclast-deficient mice are osteopetrotic and exhibit closed …
cavities formed by osteoclasts. Osteoclast-deficient mice are osteopetrotic and exhibit closed …
MCP-1 expressed by osteoclasts stimulates osteoclastogenesis in an autocrine/paracrine manner
…, R Iwasaki, H Miyamoto, S Yoshida, Y Sato… - Biochemical and …, 2009 - Elsevier
Monocyte chemoattractant protein-1 (MCP-1) is a chemokine that plays a critical role in the
recruitment and activation of leukocytes. Here, we describe that multinuclear osteoclast …
recruitment and activation of leukocytes. Here, we describe that multinuclear osteoclast …
[HTML][HTML] Hyperglycemia promotes Schwann cell de-differentiation and de-myelination via sorbitol accumulation and Igf1 protein down-regulation
W Hao, S Tashiro, T Hasegawa, Y Sato… - Journal of Biological …, 2015 - ASBMB
Diabetes mellitus (DM) is frequently accompanied by complications, such as peripheral nerve
neuropathy. Schwann cells play a pivotal role in regulating peripheral nerve function and …
neuropathy. Schwann cells play a pivotal role in regulating peripheral nerve function and …
[HTML][HTML] Stat3 as a potential therapeutic target for rheumatoid arthritis
T Oike, Y Sato, T Kobayashi, K Miyamoto… - Scientific reports, 2017 - nature.com
Rheumatoid arthritis (RA) is a multi-factorial disease characterized by chronic inflammation
and destruction of multiple joints. To date, various biologic treatments for RA such as anti-…
and destruction of multiple joints. To date, various biologic treatments for RA such as anti-…
Aldehyde‐stress resulting from Aldh2 mutation promotes osteoporosis due to impaired osteoblastogenesis
…, K Miyamoto, R Iwasaki, Y Sato… - Journal of Bone and …, 2012 - academic.oup.com
Osteoporosis is a complex disease with various causes, such as estrogen loss, genetics,
and aging. Here we show that a dominant‐negative form of aldehyde dehydrogenase 2 (ALDH2…
and aging. Here we show that a dominant‐negative form of aldehyde dehydrogenase 2 (ALDH2…
[HTML][HTML] Smad2/3 proteins are required for immobilization-induced skeletal muscle atrophy
T Tando, A Hirayama, M Furukawa, Y Sato… - Journal of Biological …, 2016 - ASBMB
Skeletal muscle atrophy promotes muscle weakness, limiting activities of daily living. However,
mechanisms underlying atrophy remain unclear. Here, we show that skeletal muscle …
mechanisms underlying atrophy remain unclear. Here, we show that skeletal muscle …
[HTML][HTML] Elevation of pro-inflammatory cytokine levels following anti-resorptive drug treatment is required for osteonecrosis development in infectious osteomyelitis
M Morita, R Iwasaki, Y Sato, T Kobayashi… - Scientific reports, 2017 - nature.com
Various conditions, including bacterial infection, can promote osteonecrosis. For example,
following invasive dental therapy with anti-bone resorptive agents, some patients develop …
following invasive dental therapy with anti-bone resorptive agents, some patients develop …
[HTML][HTML] Osteonecrosis development by tooth extraction in zoledronate treated mice is inhibited by active vitamin D analogues, anti-inflammatory agents or antibiotics
T Soma, R Iwasaki, Y Sato, T Kobayashi, E Ito… - Scientific reports, 2022 - nature.com
Invasive dental treatment such as tooth extraction following treatment with strong anti-bone
resorptive agents, including bisphosphonates and denosumab, reportedly promotes …
resorptive agents, including bisphosphonates and denosumab, reportedly promotes …