Amyloid fibrils and amorphous aggregates are two types of aberrant aggregates associated
with protein misfolding diseases. Although they differ in morphology, the two forms are often …

Oligomeric species of various proteins are linked to the pathogenesis of different neurodegenerative
disorders. Consequently, there is intense focus on the discovery of novel inhibitors, …

Because of the insolubility and polymeric properties of amyloid fibrils, techniques used
conventionally to analyze protein structure and dynamics have often been hampered. …

Novel 2‘-deoxycytidine antimetabolites, specifically several 2‘-modified 2‘-deoxy-4‘-thiocytidines,
were synthesized as potential new antineoplastic agents. Methyl 3-O-…

We report on the synthesis and the biological evaluation of a series of α-1-C-alkylated 1,4-dideoxy-1,4-imino-l-arabinitol
(LAB) derivatives. The asymmetric synthesis of the derivatives …

Nucleosides containing sulfur atoms instead of lactol oxygen have been the focus of much
recent research because of their potent biological activity. Walker1 and Secrist2 …

Aberrant protein aggregation underlies a variety of age-related neurodegenerative disorders,
including Alzheimer's and Parkinson's diseases. Little is known, however, about the …

Although many proteins possess a distinct folded structure lying at a minimum in a funneled
free energy landscape, thermal energy causes any protein to continuously access lowly …

Innate immune signaling via TLR 4 plays critical roles in pathogenesis of metabolic disorders,
but the contribution of different lipid species to metabolic disorders and inflammatory …

We report on the synthesis and biological evaluation of a series of α-1-C-alkylated 1,4-dideoxy-1,4-imino-D-arabinitol
(DAB) derivatives as pharmacological chaperones for Gaucher …