Structure of the catalytic domain of human phosphodiesterase 5 with bound drug molecules
BJ Sung, K Yeon Hwang, Y Ho Jeon, JI Lee, YS Heo… - Nature, 2003 - nature.com
Phosphodiesterases (PDEs) are a superfamily of enzymes that degrade the intracellular
second messengers cyclic AMP and cyclic GMP 1 , 2 , 3 . As essential regulators of cyclic …
second messengers cyclic AMP and cyclic GMP 1 , 2 , 3 . As essential regulators of cyclic …
Inverse agonist of estrogen-related receptor γ enhances sodium iodide symporter function through mitogen-activated protein kinase signaling in anaplastic thyroid …
Anaplastic thyroid cancer (ATC), a rare thyroid cancer with poor prognosis, is associated
with insufficient function of the sodium iodide symporter (NIS). Estrogen-related receptor γ (…
with insufficient function of the sodium iodide symporter (NIS). Estrogen-related receptor γ (…
Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125
The c‐jun N‐terminal kinase (JNK) signaling pathway is regulated by JNK‐interacting protein‐1
(JIP1), which is a scaffolding protein assembling the components of the JNK cascade. …
(JIP1), which is a scaffolding protein assembling the components of the JNK cascade. …
[HTML][HTML] Visualization of the biological behavior of tumor-associated macrophages in living mice with colon cancer using multimodal optical reporter gene imaging
We sought to visualize the migration of tumor-associated macrophages (TAMs) to tumor
lesions and to evaluate the effects of anti-inflammatory drugs on TAM-modulated tumor …
lesions and to evaluate the effects of anti-inflammatory drugs on TAM-modulated tumor …
Evaluation of therapeutic effects of natural killer (NK) cell‐based immunotherapy in mice using in vivo apoptosis bioimaging with a caspase‐3 sensor
Natural killer (NK) cell‐based immunotherapy is a promising strategy for cancer treatment,
and caspase‐3 is an important effector molecule in NK cell‐mediated apoptosis in cancers. …
and caspase‐3 is an important effector molecule in NK cell‐mediated apoptosis in cancers. …
Combined fluorescence and magnetic resonance imaging of primary macrophage migration to sites of acute inflammation using near-infrared fluorescent magnetic …
Purpose This study aimed to track the migration of primary macrophages labeled with near-infrared
(NIR) fluorescent magnetic nanoparticles toward chemically induced acute …
(NIR) fluorescent magnetic nanoparticles toward chemically induced acute …
[HTML][HTML] T cell microvilli constitute immunological synaptosomes that carry messages to antigen-presenting cells
…, JH Park, BN Jeon, CH Kim, Y Jun, YM Hyun… - Nature …, 2018 - nature.com
Microvilli on T cells have been proposed to survey surfaces of antigen-presenting cells (APC)
or facilitate adhesion under flow; however, whether they serve essential functions during T …
or facilitate adhesion under flow; however, whether they serve essential functions during T …
[HTML][HTML] Inhibition of Pendrin by a small molecule reduces Lipopolysaccharide-induced acute Lung Injury
…, D Song, YM Hyun, JH Ryu, JK Seong, Y Jeon… - Theranostics, 2020 - ncbi.nlm.nih.gov
Rationale: Pendrin is encoded by SLC26A4 and its mutation leads to congenital hearing
loss. Additionally, pendrin is up-regulated in inflammatory airway diseases such as chronic …
loss. Additionally, pendrin is up-regulated in inflammatory airway diseases such as chronic …
Design, synthesis, and evaluation of 2-aryl-7-(3′, 4′-dialkoxyphenyl)-pyrazolo [1, 5-a] pyrimidines as novel PDE-4 inhibitors
…, Z No, YL Hyun, YS Cho, NS Kang, DJ Jeon - Bioorganic & medicinal …, 2010 - Elsevier
Described herein is design, synthesis, and biological evaluation of novel series of 2-aryl-7-(3′,4′-dialkoxyphenyl)-pyrazolo[1,5-a]pyrimidines
acting as inhibitors of type 4 …
acting as inhibitors of type 4 …
Production of a replicating retroviral vector expressing reovirus fast protein for cancer gene therapy
YH Jeon, YT Jung - Journal of Virological Methods, 2022 - Elsevier
… Author links open overlay panel Young Hyun Jeon , Yong-Tae Jung … Yong-Tae Jung
designed research and finalized the manuscript ; Young Hyun Jeon performed research and …
designed research and finalized the manuscript ; Young Hyun Jeon performed research and …