OPC-41061, a highly potent human vasopressin V2-receptor antagonist: pharmacological profile and aquaretic effect by single and multiple oral dosing in rats
…, T Hirano, T Onogawa, T Yamashita, Y Yamada… - Journal of pharmacology …, 1998 - ASPET
The pharmacological profile and the acute and chronic aquaretic effects of OPC-41061, a
novel nonpeptide human arginine vasopressin (AVP) V 2 -receptor antagonist, were …
novel nonpeptide human arginine vasopressin (AVP) V 2 -receptor antagonist, were …
[HTML][HTML] Disruption of nuclear vitamin D receptor gene causes enhanced thrombogenicity in mice
…, M Yamashita, T Sudo, H Hayashi, Y Yamada… - Journal of Biological …, 2004 - ASBMB
Vitamin D metabolites influence the expression of various genes involved in calcium homeostasis,
cell differentiation, and regulation of the immune system. Expression of these genes is …
cell differentiation, and regulation of the immune system. Expression of these genes is …
Studies on 4 (1H)-quinazolinones. 5. Synthesis and antiinflammatory activity of 4 (1H)-quinazolinone derivatives
K Ozaki, Y Yamada, T Oine, T Ishizuka… - Journal of medicinal …, 1985 - ACS Publications
A number of new 4 (lH)-quinazolinones were synthesized and evaluated in the carrageenin-induced
paw edema test. Most of the compounds were obtained by the cyclization of the …
paw edema test. Most of the compounds were obtained by the cyclization of the …
S1P–S1PR2 axis mediates homing of muse cells into damaged heart for long-lasting tissue repair and functional recovery after acute myocardial infarction
Y Yamada, S Wakao, Y Kushida… - Circulation …, 2018 - Am Heart Assoc
Rationale: Multilineage-differentiating stress enduring (Muse) cells, pluripotent marker stage-specific
embryonic antigen-3 + cells, are nontumorigenic endogenous pluripotent-like stem …
embryonic antigen-3 + cells, are nontumorigenic endogenous pluripotent-like stem …
[HTML][HTML] International consensus definitions of clinical trial outcomes for kidney failure: 2020
…, DC Wheeler, BO Wolthers, HM Wright, Y Yamada… - Kidney international, 2020 - Elsevier
Kidney failure is an important outcome for patients, clinicians, researchers, healthcare systems,
payers, and regulators. However, no harmonized international consensus definitions of …
payers, and regulators. However, no harmonized international consensus definitions of …
Studies on biologically active halogenated compounds. 1. Synthesis and central nervous system depressant activity of 2-(fluoromethyl)-3-aryl-4 (3H)-quinazolinone …
J Tani, Y Yamada, T Oine, T Ochiai… - Journal of Medicinal …, 1979 - ACS Publications
Some 2-(fluoromethyl) analogues of2-methyl-3-aryl-4 (3/f)-quinazolinones have been
synthesized and screened for CNS activities. It was shown that the 2-(fluoromethyl) analogues …
synthesized and screened for CNS activities. It was shown that the 2-(fluoromethyl) analogues …
Echocardiographic evaluation of long-term effects of exercise on left ventricular hypertrophy and function in professional bicyclists.
T Nishimura, Y Yamada, C Kawai - Circulation, 1980 - Am Heart Assoc
Echocardiographic examinations were performed in 60 professional bicyclists and control
subjects to determine the effects of exercise on left ventricular hypertrophy and function. The …
subjects to determine the effects of exercise on left ventricular hypertrophy and function. The …
Metformin enhances autophagy and provides cardioprotection in δ-sarcoglycan deficiency-induced dilated cardiomyopathy
…, T Watanabe, T Kawaguchi, Y Yamada… - Circulation: Heart …, 2019 - Am Heart Assoc
Background: Metformin is a popular antidiabetic agent that is also used to treat heart failure
patients with type 2 diabetes mellitus. Several reports suggest that metformin may also have …
patients with type 2 diabetes mellitus. Several reports suggest that metformin may also have …
MicroRNA-145 repairs infarcted myocardium by accelerating cardiomyocyte autophagy
K Higashi, Y Yamada, S Minatoguchi… - American Journal …, 2015 - journals.physiology.org
We investigated whether microRNA-145 (miR-145) has a cardioprotective effect in a rabbit
model of myocardial infarction (MI) and in H9c2 rat cardiomyoblasts. Rabbits underwent 30 …
model of myocardial infarction (MI) and in H9c2 rat cardiomyoblasts. Rabbits underwent 30 …
[HTML][HTML] International Society of Nephrology first consensus guidance for preclinical animal studies in translational nephrology
Preclinical tests in animal models are key steps in early drug development. Consequently,
the International Society of Nephrology held a consensus meeting that connected experts in …
the International Society of Nephrology held a consensus meeting that connected experts in …