PSMA-based radioligand therapy for metastatic castration-resistant prostate cancer: the Bad Berka experience since 2013

…, K Niepsch, M Sayeg, Y Leshch… - Journal of Nuclear …, 2016 - Soc Nuclear Med
A potential milestone in personalized nuclear medicine is theranostics of metastatic
castration-resistant prostate cancer (mCRPC) based on molecular imaging using PET/CT with 68 Ga-…

Glycoconjugated amphiphilic polymers via click-chemistry for the encapsulation of quantum dots

…, AM Kreuziger, D Alpers, A Jacobsen, Y Leshch… - Langmuir, 2013 - ACS Publications
Herein, we present a strategy for the glycoconjugation of nanoparticles (NPs), with a special
focus on fluorescent quantum dots (QDs), recently described by us as “preassembly” …

Synthesis of fluorinated ketoheptoses as specific diagnostic agents

D Waschke, Y Leshch, J Thimm, U Himmelreich… - 2012 - Wiley Online Library
The straightforward syntheses of six regioisomeric mono‐ and difluorinated D‐manno‐heptulose
and Kamusol analogues, which use electrophilic or nucleophilic fluorinaton, are …

19F-heptuloses as tools for the non-invasive imaging of GLUT2-expressing cells

…, T Mandrup-Poulsen, D Waschke, Y Leshch… - Archives of biochemistry …, 2012 - Elsevier
Suitable analogs of d-mannoheptulose are currently considered as possible tools for the
non-invasive imaging of pancreatic islet insulin-producing cells. Here, we examined whether 19 …

Expedient and versatile formation of novel amino-deoxy-ketoheptuloses

Y Leshch, A Jacobsen, J Thimm, J Thiem - Organic letters, 2013 - ACS Publications
Novel monoketoheptuloses have been synthesized employing an amination step in a pre-
and/or post-C1 chain elongation using a Petasis reagent by starting from aldohexoses or …

The shortage of approved 68Ge/68Ga generators-incoming material inspection and GMP compliant use of non-approved generators

D Mueller, A Fuchs, Y Leshch, M Proehl - 2019 - Soc Nuclear Med
1059 Objectives: Due to the use of the positron emitter 68 Ga in radiopharmaceuticals for
the diagnosis of malignant tumors using PET / CT, the global demand for 68 Ge/ 68 Ga …

d-Gluco-hept-2-ulose and Novel Deoxyfluoro Derivatives as Seven-Carbon Analogues of F-Deoxy-d-glucose (FDG)

Y Leshch, D Waschke, J Thimm, J Thiem - Synthesis, 2011 - thieme-connect.com
Ketoheptoses, seven-carbon sugars, were recognized to display pharmacological properties
that are potentially suitable for in vivo diagnostic of diabetes and cancers using ¹9 F-MRI. …

First Results of Cyclotron Produced 68Ga Using Solid Targets.

…, S Senftleben, M Proehl, A Fuchs, Y Leshch - 2019 - Soc Nuclear Med
1163 Objectives: Due to the use of the positron emitter 68 Ga in radiopharmaceuticals for the
diagnosis of malignant tumors using PET / CT, the demand on this short live radionuclide …

[PDF][PDF] High-Performance Radiopharmacy: The Base for Precision Oncology

D Müller, A Fuchs, Y Leshch, P Schulze… - Beyond Becquerel and …, 2024 - library.oapen.org
The Zentralklinik Bad Berka is a privately financed hospital, and it is not a university hospital.
Since it is not located in the immediate vicinity of a large city, one could assume that it is …

Radiolabeling and stability of FAP-seeking radiopharmaceuticals for radio-molecular imaging and therapy

D Mueller, A Fuchs, Y Leshch, P Schulze, A Singh… - 2020 - Soc Nuclear Med
1129 Introduction: Cancer-associated fibroblast activation protein is a high potential target
for radio-molecular imaging and therapy. This protein is expressed on cancer-associated …