Image-guided synthesis reveals potent blood-brain barrier permeable histone deacetylase inhibitors
YJ Seo, Y Kang, L Muench, A Reid… - ACS chemical …, 2014 - ACS Publications
Recent studies have revealed that several histone deacetylase (HDAC) inhibitors, which
are used to study/treat brain diseases, show low blood-brain barrier (BBB) penetration. In …
are used to study/treat brain diseases, show low blood-brain barrier (BBB) penetration. In …
Quantitative susceptibility mapping identifies inflammation in a subset of chronic multiple sclerosis lesions
UW Kaunzner, Y Kang, S Zhang, E Morris, Y Yao… - Brain, 2019 - academic.oup.com
Chronic active multiple sclerosis lesions, characterized by a hyperintense rim of iron-enriched,
activated microglia and macrophages, have been linked to greater tissue damage. Post-…
activated microglia and macrophages, have been linked to greater tissue damage. Post-…
Noninvasive PK11195‐PET image analysis techniques can detect abnormal cerebral microglial activation in Parkinson's disease
Y Kang, PD Mozley, A Verma, D Schlyer… - Journal of …, 2018 - Wiley Online Library
BACKGROUND AND PURPOSE Neuroinflammation has been implicated in the pathophysiology
of Parkinson's disease (PD), which might be influenced by successful neuroprotective …
of Parkinson's disease (PD), which might be influenced by successful neuroprotective …
Longitudinal change in TSPO PET imaging in progressive multiple sclerosis
Y Kang, S Pandya, N Zinger… - Annals of Clinical …, 2021 - Wiley Online Library
The objective of this pilot study was to assess a 2‐year change in innate immune burden in
15 progressive multiple sclerosis (MS) patients using PK11195‐PET. Sixteen age‐matched …
15 progressive multiple sclerosis (MS) patients using PK11195‐PET. Sixteen age‐matched …
Longitudinal alterations in gamma-aminobutyric acid (GABAA) receptor availability over ∼ 1 year following traumatic brain injury
Longitudinal alterations of gamma-aminobutyric acid (GABA A ) receptor availability
following traumatic brain injury have remained uncharacterized and may reflect changes in …
following traumatic brain injury have remained uncharacterized and may reflect changes in …
Transient and chronic seizure‐induced inflammation in human focal epilepsy
In animal models, inflammation is both a cause and consequence of seizures. Less is
known about the role of inflammation in human epilepsy. We performed positron emission …
known about the role of inflammation in human epilepsy. We performed positron emission …
[HTML][HTML] Neurophysiological biomarkers of Parkinson's disease
…, PD Mozley, C Henchcliffe, Y Kang… - Journal of …, 2020 - content.iospress.com
Background: There is a need for reliable and robust Parkinson’s disease biomarkers that
reflect severity and are sensitive to disease modifying investigational therapeutics. Objective: …
reflect severity and are sensitive to disease modifying investigational therapeutics. Objective: …
[HTML][HTML] Naloxone's dose-dependent displacement of [11C]carfentanil and duration of receptor occupancy in the rat brain
Y Kang, KA O'Conor, AC Kelleher, J Ramsey… - Scientific reports, 2022 - nature.com
The continuous rise in opioid overdoses in the United States is predominantly driven by very
potent synthetic opioids, mostly fentanyl and its derivatives (fentanyls). Although naloxone (…
potent synthetic opioids, mostly fentanyl and its derivatives (fentanyls). Although naloxone (…
18F‐FPEB PET/CT Shows mGluR5 Upregulation in Parkinson's Disease
Y Kang, C Henchcliffe, A Verma… - Journal of …, 2019 - Wiley Online Library
BACKGROUND AND PURPOSE Dopamine and glutamate reciprocally regulate each other
in some of the neurocircuits affected by Parkinson's disease (PD). The objective of this pilot …
in some of the neurocircuits affected by Parkinson's disease (PD). The objective of this pilot …
Reduction of PK11195 uptake observed in multiple sclerosis lesions after natalizumab initiation
UW Kaunzner, Y Kang, E Monohan, PJ Kothari… - Multiple sclerosis and …, 2017 - Elsevier
Objective The objective of this study is to longitudinally analyze the uptake of [ 11 C]PK11195-PET
in multiple sclerosis patients after 3 and 6 months of natalizumab treatment. Methods …
in multiple sclerosis patients after 3 and 6 months of natalizumab treatment. Methods …