V1a vasopressin receptors maintain normal blood pressure by regulating circulating blood volume and baroreflex sensitivity

…, R Oikawa, Y Kawahara, Y Kiyono… - Proceedings of the …, 2006 - National Acad Sciences
Arginine-vasopressin (AVP) is a hormone that is essential for both osmotic and cardiovascular
homeostasis, and exerts important physiological regulation through three distinct …

Cytotoxic effects of γδ T cells expanded ex vivo by a third generation bisphosphonate for cancer immunotherapy

…, M Nogawa, T Yuasa, Y Kiyono… - … journal of cancer, 2005 - Wiley Online Library
Nitrogen containing‐bisphosphonates (N‐BPs), widely used to treat bone diseases, have
direct antitumor effects via the inactivation of Ras proteins. In addition to the direct antitumor …

The use of nanoimprinted scaffolds as 3D culture models to facilitate spontaneous tumor cell migration and well-regulated spheroid formation

…, M Kobayashi, H Namiki, Y Kuroda, Y Kiyono… - Biomaterials, 2011 - Elsevier
Two-dimensional (2D) cell cultures are essential for drug development and tumor research.
However, the limitations of 2D cultures are widely recognized, and a better technique is …

Increased oxidative stress is related to disease severity in the ALS motor cortex: A PET study

…, O Yamamura, T Mori, T Hamano, Y Kiyono… - Neurology, 2015 - AAN Enterprises
Objective: To investigate cerebral oxidative stress based on an over-reductive state caused
by mitochondrial dysfunction and its relationship to disease severity in patients with …

[HTML][HTML] Fatty acid synthase is a key target in multiple essential tumor functions of prostate cancer: uptake of radiolabeled acetate as a predictor of the targeted therapy …

…, T Furukawa, N Oyama, Y Hasegawa, Y Kiyono… - PloS one, 2013 - journals.plos.org
Fatty acid synthase (FASN) expression is elevated in several cancers, and this over-expression
is associated with poor prognosis. Inhibitors of FASN, such as orlistat, reportedly show …

Cytosolic acetyl‐CoA synthetase affected tumor cell survival under hypoxia: the possible function in tumor acetyl‐CoA/acetate metabolism

…, T Furukawa, H Yoshii, T Mori, Y Kiyono… - Cancer …, 2009 - Wiley Online Library
Understanding tumor‐specific metabolism under hypoxia is important to find novel targets for
antitumor drug design. Here we found that tumor cells expressed higher levels of cytosolic …

18F-FES and 18F-FDG PET for differential diagnosis and quantitative evaluation of mesenchymal uterine tumors: correlation with immunohistochemical analysis

Z Zhao, Y Yoshida, T Kurokawa, Y Kiyono… - Journal of Nuclear …, 2013 - Soc Nuclear Med
The aim of this study was to investigate the relationship between the tumor uptake of 16α-
18 F-fluoro-17β-estradiol ( 18 F-FES) and 18 F-FDG using PET and expressions of sex …

Functional images reflect aggressiveness of endometrial carcinoma: estrogen receptor expression combined with 18F-FDG PET

T Tsujikawa, Y Yoshida, T Kudo, Y Kiyono… - Journal of Nuclear …, 2009 - Soc Nuclear Med
The grade of histologic differentiation is one of the most important prognostic factors in
patients with endometrial carcinoma and postoperative staging. The aim of this study was to …

Pathophysiologic correlation between 62Cu-ATSM and 18F-FDG in lung cancer

…, T Kudo, Y Demura, Y Umeda, Y Kiyono… - Journal of Nuclear …, 2009 - Soc Nuclear Med
The purpose of this study was to delineate the differences in intratumoral uptake and tracer
distribution of 62 Cu-diacetyl-bis(N 4 -methylthiosemicarbazone) ( 62 Cu-ATSM), a well-…

γδT cells kill myeloma cells by sensing mevalonate metabolites and ICAM-1 molecules on cell surface

…, K Taniguchi, M Okamoto, K Shimura, Y Kiyono… - Biochemical and …, 2007 - Elsevier
We evaluated the mechanism of recognition of myeloma cells by γδT cells. The expanded
γδT cells killed RPMI8226 and U266 myeloma cells in a γδT-cell dose-dependent manner. …