Inhibition of myocardial endothelin pathway improves long-term survival in heart failure
…, M Kobayashi, I Yamaguchi, K Goto, Y Sugishita - Nature, 1996 - nature.com
OCCLUSION of the diseased coronary artery in humans causes acute myocardial infarction,
survivors of which have a high risk for the development of chronic heart failure 1 . Cardiac …
survivors of which have a high risk for the development of chronic heart failure 1 . Cardiac …
Coronary circulation in dogs with an experimental decrease in aortic compliance
…, S Ohtsuka, M Kakihana, Y Sugishita - Journal of the American …, 1993 - Elsevier
Objectives. This study was designed to investigate the effects of decreased aortic
compliance on the coronary circulation. Background. A decrease in aortic compliance due to …
compliance on the coronary circulation. Background. A decrease in aortic compliance due to …
Endogenous endothelin-1 participates in the maintenance of cardiac function in rats with congestive heart failure: marked increase in endothelin-1 production in the …
…, Y Kasuya, M Ihara, I Yamaguchi, K Goto, Y Sugishita - Circulation, 1996 - Am Heart Assoc
Background Although it was demonstrated that circulating endothelin-1 (ET-1) levels are
elevated in congestive heart failure (CHF), the production and roles of ET-1 in the failing heart …
elevated in congestive heart failure (CHF), the production and roles of ET-1 in the failing heart …
[HTML][HTML] Chronically decreased aortic distensibility causes deterioration of coronary perfusion during increased left ventricular contraction
…, M Kakihana, H Watanabe, Y Sugishita - Journal of the American …, 1994 - Elsevier
Objectives. This study investigated the long-term effects of decreased aortic distensibility on
the heart in relation to coronary perfusion. Background.Aortic distensibility is decreased in …
the heart in relation to coronary perfusion. Background.Aortic distensibility is decreased in …
Increased production of endothelin‐1 in the hypertrophied rat heart due to pressure overload
Endothelin‐1 (ET‐1) has been demonstrated to induce hypertrophy in cultured cardiac myocytes.
We investigated the production of ET‐1 in the heart of aorta‐banded rats in vivo. Seven …
We investigated the production of ET‐1 in the heart of aorta‐banded rats in vivo. Seven …
Involvement of endothelin in the regulation of human vascular tonus. Potent vasoconstrictor effect and existence in endothelial cells.
…, T Ishikawa, M Yanagisawa, S Kimura, Y Sugishita… - Circulation, 1990 - Am Heart Assoc
Endothelin, a recently discovered endothelium-derived peptide, has been reported to
produce potent vasoconstriction in various vessels of experimental animals. To study the …
produce potent vasoconstriction in various vessels of experimental animals. To study the …
Effect of exercise on left ventricular diastolic filling in athletes and nonathletes
M Matsuda, Y Sugishita, S Koseki, I Ito… - Journal of Applied …, 1983 - journals.physiology.org
To evaluate the effect of exercise on left ventricular diastolic filling, the following were
measured at rest and during exercise in 14 control subjects and 15 athletes, using digitized M-…
measured at rest and during exercise in 14 control subjects and 15 athletes, using digitized M-…
Reliability of non-invasive estimates of pulmonary hypertension by pulsed Doppler echocardiography.
M Matsuda, T Sekiguchi, Y Sugishita, K Kuwako, K Iida… - Heart, 1986 - heart.bmj.com
The duration of the acceleration phase of pulmonary systolic flow was measured by pulsed
Doppler echocardiography in 39 normal subjects and 67 patients with heart disease to …
Doppler echocardiography in 39 normal subjects and 67 patients with heart disease to …
Decreased aortic compliance aggravates subendocardial ischaemia in dogs with stenosed coronary artery
…, S Ohtsuka, M Kakihana, Y Sugishita - Cardiovascular …, 1992 - academic.oup.com
Objectives The existence of decreased aortic compliance due to arteriosclerosis has been
documented in patients with coronary artery disease. The aim of this study was to investigate …
documented in patients with coronary artery disease. The aim of this study was to investigate …
Randomized, double-blind, placebo-controlled study of supplemental vitamin E on attenuation of the development of nitrate tolerance
H Watanabe, M Kakihana, S Ohtsuka, Y Sugishita - Circulation, 1997 - Am Heart Assoc
Background The attenuation of intracellular production of cGMP has been known to be a
mechanism of nitrate tolerance. A recent in vitro study showed an increase in superoxide levels …
mechanism of nitrate tolerance. A recent in vitro study showed an increase in superoxide levels …