Programmed death–ligand 1 (PD-L1) expression on tumor cells is essential for T cell impairment,
and PD-L1 blockade therapy has shown unprecedented durable responses in several …

A novel copper-catalyzed decarboxylative oxyalkylation of alkynyl carboxylic acids with ketones
and alkylnitriles via direct C(sp 3 )–H bond functionalization to construct new C–C bonds …

An oxidative radical cascade cyclization of 2-cyano-3-arylaniline derived acrylamides with
hydrocarbons is described. The present reaction exhibits a wide substrate scope, and …

Purpose Tryptophan metabolism via indoleamine 2,3-dioxygenase (IDO)-mediated kynurenine
pathway plays a role in immunomodulation and has been emerging as a plausible target …

An oxidative decarboxylative cascade cyclization of α-keto acids with 2-cyano-3-arylaniline-derived
acrylamides was developed. This cascade reaction exhibits a broad substrate scope…

A copper-catalyzed decarboxylative cycloaddition of propiolic acids, azides, and arylboronic
acids is described. The present reaction provides an efficient and convenient method for the …

Abnormal tryptophan metabolism via the kynurenine pathway is involved in the pathophysiology
of a variety of human diseases including cancers. α- 11 C-methyl-l-tryptophan ( 11 C-…

Novel decarboxylative oxyacyloxylation of propiolic acids has been developed. This reaction
provides an efficient access to alkynyl-containing α-acyloxy ketones from readily available …

Purpose Fluorine-18 labeled tryptophan analog l-1-[ 18 F]fluoroethyl-tryptophan (l-1-[ 18 F]FETrp)
was designed for positron emission tomography (PET) imaging of cancer by dual …

The first asymmetric aza-Friedel-Crafts reaction of 2-naphthol with tosylimines was
developed via a dinuclear zinc catalyst (up to 98% ee). It provided a new method for the …