Objective Polypharmacy has been linked to a myriad of adverse consequences, and escalating
rates of polypharmacy present an emerging concern, particularly among older adults. …

This report describes the characterization of INCB3344, a novel, potent and selective small
molecule antagonist of the mouse CCR2 receptor. The lack of rodent cross-reactivity inherent …

68 Ga-DOTATOC, a somatostatin receptor–targeted ligand, has been used clinically in Europe
over the past decade for imaging neuroendocrine tumors (NETs). It appears to be quite …

Background Total knee arthroplasty is an effective treatment when nonsurgical treatments
fail, but it is associated with risk of complications which may be increased in advanced age. …

Prior case reports and observational studies indicate that intravenous immune globulin (IVIg)
products may cause thromboembolic events (TEEs), leading the FDA to require a boxed …

Perturbation of organic anion transporter (OAT) 1- and OAT3-mediated transport can alter
the exposure, efficacy, and safety of drugs. Although there have been reports of the …

The covalent conjugation of polyethylene glycol (PEG, typical MW > 10k) to therapeutic peptides
and proteins is a well-established approach to improve their pharmacokinetic properties …

This paper discusses the effect of SO 3 dopants on the M 1 polymorph formation and
mechanical properties of alite containing a high content of MgO. The structure of the M 1 alite is …

As the central hub of the metabolism machinery, the mammalian target of rapamycin
complex 2 (mTORC2) has been well studied in lymphocytes. As an obligatory component of …

JAK2 kinase inhibitors are a promising new class of agents for the treatment of myeloproliferative
neoplasms and have potential for the treatment of other diseases possessing a …