Establishing percent resection and residual volume thresholds affecting survival and recurrence for patients with newly diagnosed intracranial glioblastoma

…, M Hernandez-Hermann, L Gomez, X Ye… - Neuro …, 2014 - academic.oup.com
Introduction Surgery is first-line therapy for glioblastoma, and there is evidence that gross
total resection is associated with improved survival. Gross total resection, however, is not …

Immunosuppression in patients with high-grade gliomas treated with radiation and temozolomide

SA Grossman, X Ye, G Lesser, A Sloan, H Carraway… - Clinical cancer …, 2011 - AACR
Purpose: Patients with high-grade gliomas (HGG) routinely receive radiation, temozolomide,
and glucocorticoids. As each of these is immunosuppressive, we conducted a prospective, …

A phase I/II trial of hydroxychloroquine in conjunction with radiation therapy and concurrent and adjuvant temozolomide in patients with newly diagnosed glioblastoma …

MR Rosenfeld, X Ye, JG Supko, S Desideri… - Autophagy, 2014 - Taylor & Francis
Preclinical studies indicate autophagy inhibition with hydroxychloroquine (HCQ) can augment
the efficacy of DNA-damaging therapy. The primary objective of this trial was to determine …

Survival of patients with newly diagnosed glioblastoma treated with radiation and temozolomide in research studies in the United States

SA Grossman, X Ye, S Piantadosi, S Desideri… - Clinical cancer …, 2010 - AACR
Purpose: Novel agents are currently combined with radiation and temozolomide (RT + TMZ)
in newly diagnosed glioblastoma using overall survival as the primary end point. Results of …

Detection of tumor-derived DNA in cerebrospinal fluid of patients with primary tumors of the brain and spinal cord

…, JD Weingart, JP Wolinsky, X Ye… - Proceedings of the …, 2015 - National Acad Sciences
Cell-free DNA shed by cancer cells has been shown to be a rich source of putative tumor-specific
biomarkers. Because cell-free DNA from brain and spinal cord tumors cannot usually …

Combination therapy with anti-PD-1, anti-TIM-3, and focal radiation results in regression of murine gliomas

…, M Sheu, AM Martin, BM Tyler, PT Tran, X Ye… - Clinical Cancer …, 2017 - AACR
Purpose: Checkpoint molecules like programmed death-1 (PD-1) and T-cell immunoglobulin
mucin-3 (TIM-3) are negative immune regulators that may be upregulated in the setting of …

PD-L1 (B7-H1) expression and the immune tumor microenvironment in primary and metastatic breast carcinomas

A Cimino-Mathews, E Thompson, JM Taube, X Ye… - Human pathology, 2016 - Elsevier
Programmed death ligand 1 (PD-L1) expression by tumor-infiltrating lymphocytes (TILs) and
tumor cells in breast cancer has been reported, but the relationships between PD-L1 …

Detection of human brain cancer infiltration ex vivo and in vivo using quantitative optical coherence tomography

C Kut, KL Chaichana, J Xi, SM Raza, X Ye… - Science translational …, 2015 - science.org
More complete brain cancer resection can prolong survival and delay recurrence. However,
it is challenging to distinguish cancer from noncancer tissues intraoperatively, especially at …

Concurrent immune checkpoint inhibitors and stereotactic radiosurgery for brain metastases in non-small cell lung cancer, melanoma, and renal cell carcinoma

L Chen, J Douglass, L Kleinberg, X Ye… - International Journal of …, 2018 - Elsevier
Purpose To characterize the effect of concurrent stereotactic radiosurgery–stereotactic radiation
therapy (SRS-SRT) and immune checkpoint inhibitors on patient outcomes and safety in …

TIGIT and PD-1 dual checkpoint blockade enhances antitumor immunity and survival in GBM

…, A Wu, Y Xia, T Garzon-Muvdi, C Jackson, X Ye… - …, 2018 - Taylor & Francis
The use of inhibitory checkpoint blockade in the management of glioblastoma has been
studied in both preclinical and clinical settings. TIGIT is a novel checkpoint inhibitor recently …