Establishing percent resection and residual volume thresholds affecting survival and recurrence for patients with newly diagnosed intracranial glioblastoma
…, M Hernandez-Hermann, L Gomez, X Ye… - Neuro …, 2014 - academic.oup.com
Introduction Surgery is first-line therapy for glioblastoma, and there is evidence that gross
total resection is associated with improved survival. Gross total resection, however, is not …
total resection is associated with improved survival. Gross total resection, however, is not …
Immunosuppression in patients with high-grade gliomas treated with radiation and temozolomide
SA Grossman, X Ye, G Lesser, A Sloan, H Carraway… - Clinical cancer …, 2011 - AACR
Purpose: Patients with high-grade gliomas (HGG) routinely receive radiation, temozolomide,
and glucocorticoids. As each of these is immunosuppressive, we conducted a prospective, …
and glucocorticoids. As each of these is immunosuppressive, we conducted a prospective, …
A phase I/II trial of hydroxychloroquine in conjunction with radiation therapy and concurrent and adjuvant temozolomide in patients with newly diagnosed glioblastoma …
MR Rosenfeld, X Ye, JG Supko, S Desideri… - Autophagy, 2014 - Taylor & Francis
Preclinical studies indicate autophagy inhibition with hydroxychloroquine (HCQ) can augment
the efficacy of DNA-damaging therapy. The primary objective of this trial was to determine …
the efficacy of DNA-damaging therapy. The primary objective of this trial was to determine …
Survival of patients with newly diagnosed glioblastoma treated with radiation and temozolomide in research studies in the United States
SA Grossman, X Ye, S Piantadosi, S Desideri… - Clinical cancer …, 2010 - AACR
Purpose: Novel agents are currently combined with radiation and temozolomide (RT + TMZ)
in newly diagnosed glioblastoma using overall survival as the primary end point. Results of …
in newly diagnosed glioblastoma using overall survival as the primary end point. Results of …
Detection of tumor-derived DNA in cerebrospinal fluid of patients with primary tumors of the brain and spinal cord
…, JD Weingart, JP Wolinsky, X Ye… - Proceedings of the …, 2015 - National Acad Sciences
Cell-free DNA shed by cancer cells has been shown to be a rich source of putative tumor-specific
biomarkers. Because cell-free DNA from brain and spinal cord tumors cannot usually …
biomarkers. Because cell-free DNA from brain and spinal cord tumors cannot usually …
Combination therapy with anti-PD-1, anti-TIM-3, and focal radiation results in regression of murine gliomas
Purpose: Checkpoint molecules like programmed death-1 (PD-1) and T-cell immunoglobulin
mucin-3 (TIM-3) are negative immune regulators that may be upregulated in the setting of …
mucin-3 (TIM-3) are negative immune regulators that may be upregulated in the setting of …
PD-L1 (B7-H1) expression and the immune tumor microenvironment in primary and metastatic breast carcinomas
Programmed death ligand 1 (PD-L1) expression by tumor-infiltrating lymphocytes (TILs) and
tumor cells in breast cancer has been reported, but the relationships between PD-L1 …
tumor cells in breast cancer has been reported, but the relationships between PD-L1 …
Detection of human brain cancer infiltration ex vivo and in vivo using quantitative optical coherence tomography
C Kut, KL Chaichana, J Xi, SM Raza, X Ye… - Science translational …, 2015 - science.org
More complete brain cancer resection can prolong survival and delay recurrence. However,
it is challenging to distinguish cancer from noncancer tissues intraoperatively, especially at …
it is challenging to distinguish cancer from noncancer tissues intraoperatively, especially at …
Concurrent immune checkpoint inhibitors and stereotactic radiosurgery for brain metastases in non-small cell lung cancer, melanoma, and renal cell carcinoma
Purpose To characterize the effect of concurrent stereotactic radiosurgery–stereotactic radiation
therapy (SRS-SRT) and immune checkpoint inhibitors on patient outcomes and safety in …
therapy (SRS-SRT) and immune checkpoint inhibitors on patient outcomes and safety in …
TIGIT and PD-1 dual checkpoint blockade enhances antitumor immunity and survival in GBM
The use of inhibitory checkpoint blockade in the management of glioblastoma has been
studied in both preclinical and clinical settings. TIGIT is a novel checkpoint inhibitor recently …
studied in both preclinical and clinical settings. TIGIT is a novel checkpoint inhibitor recently …