User profiles for Xianyuan Xiang

Xianyuan Xiang

Ludwigs-Maximilians-Universitaet
Verified email at mail03.med.uni-muenchen.de
Cited by 1442

[PDF][PDF] White matter aging drives microglial diversity

…, G Gouna, F Usifo, N Kannaiyan, D Fitzner, X Xiang… - Neuron, 2021 - cell.com
Aging results in gray and white matter degeneration, but the specific microglial responses
are unknown. Using single-cell RNA sequencing from white and gray matter separately, we …

Microglial activation states drive glucose uptake and FDG-PET alterations in neurodegenerative diseases

X Xiang, K Wind, T Wiedemann, T Blume… - Science translational …, 2021 - science.org
2-Deoxy-2-[ 18 F]fluoro-d-glucose positron emission tomography (FDG-PET) is widely used
to study cerebral glucose metabolism. Here, we investigated whether the FDG-PET signal is …

Enhancing protective microglial activities with a dual function TREM 2 antibody to the stalk region

…, A Sülzen, B Nuscher, H Hampel, X Xiang… - EMBO molecular …, 2020 - embopress.org
Triggering receptor expressed on myeloid cells 2 ( TREM 2) is essential for the transition of
homeostatic microglia to a disease‐associated microglial state. To enhance TREM 2 activity, …

The FTD‐like syndrome causing TREM 2 T66M mutation impairs microglia function, brain perfusion, and glucose metabolism

…, E Mracsko, B Wefers, L Groeneweg, X Xiang… - The EMBO …, 2017 - embopress.org
Genetic variants in the triggering receptor expressed on myeloid cells 2 ( TREM 2) increase
the risk for several neurodegenerative diseases including Alzheimer's disease and …

TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearance

X Xiang, G Werner, B Bohrmann, A Liesz… - EMBO molecular …, 2016 - embopress.org
Immunotherapeutic approaches are currently the most advanced treatments for Alzheimer's
disease ( AD ). Antibodies against amyloid β‐peptide (Aβ) bind to amyloid plaques and …

[HTML][HTML] The Trem2 R47H Alzheimer's risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans

X Xiang, TM Piers, B Wefers, K Zhu, A Mallach… - Molecular …, 2018 - Springer
Background The R47H variant of the Triggering Receptor Expressed on Myeloid cells 2 (TREM2)
significantly increases the risk for late onset Alzheimer’s disease. Mouse models …

[HTML][HTML] Beta-site amyloid precursor protein cleaving enzyme 1 inhibition impairs synaptic plasticity via seizure protein 6

K Zhu, X Xiang, S Filser, P Marinković, MM Dorostkar… - Biological …, 2018 - Elsevier
Background Beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) is a promising
drug target for the treatment of Alzheimer’s disease. Prolonged BACE1 inhibition interferes …

[HTML][HTML] Versatile strategies for adult neurogenesis: Avenues to repair the injured brain

J Zhao, S Liu, X Xiang, X Zhu - Neural Regeneration Research, 2024 - journals.lww.com
Brain injuries due to trauma or stroke are major causes of adult death and disability. Unfortunately,
few interventions are effective for post-injury repair of brain tissue. After a long debate …

[HTML][HTML] The Alzheimer's disease-associated protective Plcγ2-P522R variant promotes immune functions

…, P Mäkinen, H Martiskainen, W Wurst, X Xiang… - Molecular …, 2020 - Springer
Background Microglia-specific genetic variants are enriched in several neurodegenerative
diseases, including Alzheimer’s disease (AD), implicating a central role for alterations of the …

TREM2 promotes glioma progression and angiogenesis mediated by microglia/brain macrophages

…, J Zhao, H Zhang, X Zhu, H Kettenmann, X Xiang - Glia, 2023 - Wiley Online Library
Triggering receptor expressed on myeloid cell 2 (TREM2), a myeloid cell‐specific signaling
molecule, controls essential functions of microglia and impacts on the pathogenesis of …