User profiles for Xianyuan Xiang
Xianyuan XiangLudwigs-Maximilians-Universitaet Verified email at mail03.med.uni-muenchen.de Cited by 1442 |
[PDF][PDF] White matter aging drives microglial diversity
Aging results in gray and white matter degeneration, but the specific microglial responses
are unknown. Using single-cell RNA sequencing from white and gray matter separately, we …
are unknown. Using single-cell RNA sequencing from white and gray matter separately, we …
Microglial activation states drive glucose uptake and FDG-PET alterations in neurodegenerative diseases
X Xiang, K Wind, T Wiedemann, T Blume… - Science translational …, 2021 - science.org
2-Deoxy-2-[ 18 F]fluoro-d-glucose positron emission tomography (FDG-PET) is widely used
to study cerebral glucose metabolism. Here, we investigated whether the FDG-PET signal is …
to study cerebral glucose metabolism. Here, we investigated whether the FDG-PET signal is …
Enhancing protective microglial activities with a dual function TREM 2 antibody to the stalk region
…, A Sülzen, B Nuscher, H Hampel, X Xiang… - EMBO molecular …, 2020 - embopress.org
Triggering receptor expressed on myeloid cells 2 ( TREM 2) is essential for the transition of
homeostatic microglia to a disease‐associated microglial state. To enhance TREM 2 activity, …
homeostatic microglia to a disease‐associated microglial state. To enhance TREM 2 activity, …
The FTD‐like syndrome causing TREM 2 T66M mutation impairs microglia function, brain perfusion, and glucose metabolism
…, E Mracsko, B Wefers, L Groeneweg, X Xiang… - The EMBO …, 2017 - embopress.org
Genetic variants in the triggering receptor expressed on myeloid cells 2 ( TREM 2) increase
the risk for several neurodegenerative diseases including Alzheimer's disease and …
the risk for several neurodegenerative diseases including Alzheimer's disease and …
TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearance
Immunotherapeutic approaches are currently the most advanced treatments for Alzheimer's
disease ( AD ). Antibodies against amyloid β‐peptide (Aβ) bind to amyloid plaques and …
disease ( AD ). Antibodies against amyloid β‐peptide (Aβ) bind to amyloid plaques and …
[HTML][HTML] The Trem2 R47H Alzheimer's risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans
Background The R47H variant of the Triggering Receptor Expressed on Myeloid cells 2 (TREM2)
significantly increases the risk for late onset Alzheimer’s disease. Mouse models …
significantly increases the risk for late onset Alzheimer’s disease. Mouse models …
[HTML][HTML] Beta-site amyloid precursor protein cleaving enzyme 1 inhibition impairs synaptic plasticity via seizure protein 6
Background Beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) is a promising
drug target for the treatment of Alzheimer’s disease. Prolonged BACE1 inhibition interferes …
drug target for the treatment of Alzheimer’s disease. Prolonged BACE1 inhibition interferes …
[HTML][HTML] Versatile strategies for adult neurogenesis: Avenues to repair the injured brain
J Zhao, S Liu, X Xiang, X Zhu - Neural Regeneration Research, 2024 - journals.lww.com
Brain injuries due to trauma or stroke are major causes of adult death and disability. Unfortunately,
few interventions are effective for post-injury repair of brain tissue. After a long debate …
few interventions are effective for post-injury repair of brain tissue. After a long debate …
[HTML][HTML] The Alzheimer's disease-associated protective Plcγ2-P522R variant promotes immune functions
Background Microglia-specific genetic variants are enriched in several neurodegenerative
diseases, including Alzheimer’s disease (AD), implicating a central role for alterations of the …
diseases, including Alzheimer’s disease (AD), implicating a central role for alterations of the …
TREM2 promotes glioma progression and angiogenesis mediated by microglia/brain macrophages
…, J Zhao, H Zhang, X Zhu, H Kettenmann, X Xiang - Glia, 2023 - Wiley Online Library
Triggering receptor expressed on myeloid cell 2 (TREM2), a myeloid cell‐specific signaling
molecule, controls essential functions of microglia and impacts on the pathogenesis of …
molecule, controls essential functions of microglia and impacts on the pathogenesis of …