In Vitro Characterization of the Anti-PD-1 Antibody Nivolumab, BMS-936558, and In Vivo Toxicology in Non-Human Primates
C Wang, KB Thudium, M Han, XT Wang, H Huang… - Cancer immunology …, 2014 - AACR
The programmed death-1 (PD-1) receptor serves as an immunologic checkpoint, limiting
bystander tissue damage and preventing the development of autoimmunity during inflammatory …
bystander tissue damage and preventing the development of autoimmunity during inflammatory …
Mice lacking renal chloride channel, CLC-5, are a model for Dent's disease, a nephrolithiasis disorder associated with defective receptor-mediated endocytosis
…, PJ Courtoy, XT Wang, H Wang, Y Wang… - Human molecular …, 2000 - academic.oup.com
Nephrolithiasis (kidney stones) affects 5–10% of adults and is most commonly associated
with hypercalciuria, which may be due to monogenic renal tubular disorders. One such …
with hypercalciuria, which may be due to monogenic renal tubular disorders. One such …
Intrinsic immunogenicity of small cell lung carcinoma revealed by its cellular plasticity
…, MM Awad, EM Van Allen, A Lako, XT Wang… - Cancer discovery, 2021 - AACR
SCLC is poorly immunogenic, displaying modest ICB responsiveness with rare durable
activity. In profiling its plasticity, we uncover intrinsically immunogenic MHC I hi subpopulations …
activity. In profiling its plasticity, we uncover intrinsically immunogenic MHC I hi subpopulations …
Synthesis and biologic evaluation of a novel 18F-labeled adnectin as a PET radioligand for imaging PD-L1 expression
…, P Chow, J Gan, O Adelakun, XT Wang… - Journal of Nuclear …, 2018 - Soc Nuclear Med
The programmed death protein (PD-1) and its ligand (PD-L1) play critical roles in a checkpoint
pathway cancer cells exploit to evade the immune system. A same-day PET imaging …
pathway cancer cells exploit to evade the immune system. A same-day PET imaging …
Enhanced photocatalytic H2 production from glycerol solution over ZnO/ZnS core/shell nanorods prepared by a low temperature route
HX Sang, XT Wang, CC Fan, F Wang - international journal of hydrogen …, 2012 - Elsevier
A series of ZnO/ZnS core/shell nanorods with different ZnS/ZnO molar ratios was synthesized
via a new water bath route. The nanorods have a diameter of about 100 nm and a length …
via a new water bath route. The nanorods have a diameter of about 100 nm and a length …
Antigenic targeting of the human mannose receptor induces tumor immunity
…, J Lee, J Mendoza-Ramirez, XT Wang… - The Journal of …, 2007 - journals.aai.org
Pattern recognition receptors are preferentially expressed on APCs allowing selective uptake
of pathogens for the initiation of antimicrobial immunity. In particular, C-type lectin receptors…
of pathogens for the initiation of antimicrobial immunity. In particular, C-type lectin receptors…
[HTML][HTML] The mRNA of L-type calcium channel elevated in colon cancer: protein distribution in normal and cancerous colon
XT Wang, Y Nagaba, HS Cross, F Wrba… - The American Journal of …, 2000 - Elsevier
Previous reports indicate that the mRNA for the cardiac isoform of the voltage-gated L-type
calcium channel (α 1C ) is elevated in colon cancer. The aim of these experiments was to …
calcium channel (α 1C ) is elevated in colon cancer. The aim of these experiments was to …
Characterization of organic anion transporter 2 (SLC22A7): a highly efficient transporter for creatinine and species-dependent renal tubular expression
…, Y Zhang, X Qiu, C Chen, AC Lewin, XT Wang… - Drug Metabolism and …, 2015 - ASPET
The contribution of organic anion transporter OAT2 (SLC22A7) to the renal tubular secretion
of creatinine and its exact localization in the kidney are reportedly controversial. In the …
of creatinine and its exact localization in the kidney are reportedly controversial. In the …
Preclinical characterization of relatlimab, a human LAG-3–blocking antibody, alone or in combination with nivolumab
K Thudium, M Selby, JA Zorn, G Rak, XT Wang… - Cancer Immunology …, 2022 - AACR
… Our data, as well as that from Wang and colleagues in supplement (12), indicated that the
interaction between FGL1 and LAG-3 was relatively weak (>1 μmol/L; Fig. 3C and D). This …
interaction between FGL1 and LAG-3 was relatively weak (>1 μmol/L; Fig. 3C and D). This …
A Novel, Fully Human Anti–fucosyl-GM1 Antibody Demonstrates Potent In Vitro and In Vivo Antitumor Activity in Preclinical Models of Small Cell Lung Cancer
…, D Strachan, H LeBlanc, H Sun, XT Wang… - Clinical Cancer …, 2018 - AACR
Purpose: The ganglioside fucosyl-GM1 (FucGM1) is a tumor-associated antigen expressed
in a large percentage of human small cell lung cancer (SCLC) tumors, but absent in most …
in a large percentage of human small cell lung cancer (SCLC) tumors, but absent in most …