[HTML][HTML] Immunomodulation of the tumor microenvironment: turn foe into friend

H Locy, S De Mey, W De Mey, M De Ridder… - Frontiers in …, 2018 - frontiersin.org
Immunotherapy, where the patient's own immune system is exploited to eliminate tumor cells,
has become one of the most prominent new cancer treatment options in the last decade. …

[HTML][HTML] Neo-antigen mRNA vaccines

A Esprit, W de Mey, R Bahadur Shahi, K Thielemans… - Vaccines, 2020 - mdpi.com
The interest in therapeutic cancer vaccines has caught enormous attention in recent years
due to several breakthroughs in cancer research, among which the finding that successful …

Single-domain antibody nuclear imaging allows noninvasive quantification of LAG-3 expression by tumor-infiltrating leukocytes and predicts response of immune …

…, RM Awad, Y De Vlaeminck, W De Mey… - Journal of Nuclear …, 2021 - Soc Nuclear Med
Recent advances in the field of immune-oncology led to the discovery of next-generation
immune checkpoints (ICPs). Lymphocyte activation gene-3 (LAG-3), being the most widely …

RNA in cancer immunotherapy: unlocking the potential of the immune system

W De Mey, A Esprit, K Thielemans, K Breckpot… - Clinical Cancer …, 2022 - AACR
Recent advances in the manufacturing, modification, purification, and cellular delivery of
ribonucleic acid (RNA) have enabled the development of RNA-based therapeutics for a broad …

Fractionated radiation severely reduces the number of CD8+ T cells and mature antigen presenting cells within lung tumors

E Reijmen, S De Mey, W De Mey, T Gevaert… - International Journal of …, 2021 - Elsevier
Purpose The combination of standard-of-care radiation therapy (RT) with immunotherapy is
moving to the mainstream of non-small cell lung cancer treatment. Multiple preclinical …

[HTML][HTML] TNF-α-secreting lung tumor-infiltrated monocytes play a pivotal role during anti-PD-L1 immunotherapy

…, Q Lecocq, E Reijmen, W De Mey… - Frontiers in …, 2022 - frontiersin.org
Immune checkpoint blockade (ICB) of the PD-1 pathway revolutionized the survival forecast
for advanced non-small cell lung cancer (NSCLC). Yet, the majority of PD-L1 + NSCLC …

[HTML][HTML] An mRNA mix redirects dendritic cells towards an antiviral program, inducing anticancer cytotoxic stem cell and central memory CD8+ T cells

W de Mey, H Locy, K De Ridder, P De Schrijver… - Frontiers in …, 2023 - frontiersin.org
Dendritic cell (DC)-maturation stimuli determine the potency of these antigen-presenting cells
and, therefore, the quality of the T-cell response. Here we describe that the maturation of …

Targeted α-Therapy Using 225Ac Radiolabeled Single-Domain Antibodies Induces Antigen-Specific Immune Responses and Instills Immunomodulation Both …

…, K De Jonghe, W de Mey… - Journal of Nuclear …, 2023 - Soc Nuclear Med
Targeted radionuclide therapy (TRT) using targeting moieties labeled with α-particle–emitting
radionuclides (α-TRT) is an intensely investigated treatment approach as the short range …

Targeted radionuclide therapy with low and high-dose lutetium-177–labeled single domain antibodies induces distinct immune signatures in a mouse melanoma …

…, L De Beck, K De Ridder, H Locy, W De Mey… - Molecular Cancer …, 2022 - AACR
Targeted radionuclide therapy (TRT) using probes labeled with Lutetium-177 ( 177 Lu)
represents a new and growing type of cancer therapy. We studied immunologic changes in …

[HTML][HTML] Development and evaluation of nanobody tracers for noninvasive nuclear imaging of the immune-checkpoint TIGIT

…, H Ceuppens, RM Awad, T Ertveldt, W de Mey… - Frontiers in …, 2023 - frontiersin.org
Introduction T cell Ig and ITIM domain receptor (TIGIT) is a next-generation immune checkpoint
predominantly expressed on activated T cells and NK cells, exhibiting an unfavorable …