Protective effects of HOE642, a selective sodium-hydrogen exchange subtype 1 inhibitor, on cardiac ischaemia and reperfusion

W Scholz, U Albus, L Counillon… - Cardiovascular …, 1995 - academic.oup.com
Objective: The aim was to characterise the new compound HOE642 as a selective and
cardioprotective Na + /H + exchange inhibitor in various models. Methods: The effect of HOE642 …

18F-Based Pretargeted PET Imaging Based on Bioorthogonal Diels–Alder Click Chemistry

…, T Reiner, NVK Pillarsetty, WW Scholz… - Bioconjugate …, 2016 - ACS Publications
A first-of-its-kind 18 F pretargeted PET imaging approach based on the bioorthogonal
inverse electron demand Diels–Alder (IEDDA) reaction between tetrazine (Tz) and trans-…

EMD638683, a novel SGK inhibitor with antihypertensive potency

TF Ackermann, KM Boini, N Beier, W Scholz… - Cellular Physiology and …, 2011 - karger.com
The serum- and glucocorticoid-inducible kinase 1 (SGK1) is transcriptionally upregulated by
mineralocorticoids and activated by insulin. The kinase enhances renal tubular Na+-…

Site-specifically labeled CA19. 9-targeted immunoconjugates for the PET, NIRF, and multimodal PET/NIRF imaging of pancreatic cancer

…, R Sawada, BJ Agnew, WW Scholz… - Proceedings of the …, 2015 - National Acad Sciences
Molecular imaging agents for preoperative positron emission tomography (PET) and near-infrared
fluorescent (NIRF)-guided delineation of surgical margins could greatly enhance the …

Human Monoclonal Antibodies to Sialyl-Lewisa (CA19.9) with Potent CDC, ADCC, and Antitumor Activity

…, F Hong, G Ragupathi, PO Livingston, WW Scholz - Clinical Cancer …, 2011 - AACR
Purpose: The carbohydrate antigen sialyl-Lewis a (sLe a ), also known as CA19.9, is widely
expressed on epithelial tumors of the gastrointestinal tract and breast and on small-cell lung …

Juvenile Huntington chorea: clinical, ultrastructural, and biochemical studies

HH GOEBEL, R HEIPERTZ, W SCHOLZ, K IQBAL… - Neurology, 1978 - AAN Enterprises
A brain biopsy from a 20-year-old patient whose clinical course was marked by progressive
dementia and chorea since age 10 years showed increased amounts of lipofuscin, abnormal …

Establishment of the In Vivo Efficacy of Pretargeted Radioimmunotherapy Utilizing Inverse Electron Demand Diels-Alder Click Chemistry

…, D Abdel-Atti, KM Cunanan, S Carlin, WW Scholz… - Molecular cancer …, 2017 - AACR
The pretargeting system based on the inverse electron demand Diels-Alder reaction (IEDDA)
between trans-cyclooctene (TCO) and tetrazine (Tz) combines the favorable …

Pretargeted immuno-PET of pancreatic cancer: overcoming circulating antigen and internalized antibody to reduce radiation doses

…, D Abdel-Atti, R Sawada, WW Scholz… - Journal of Nuclear …, 2016 - Soc Nuclear Med
5B1 is a fully human, monoclonal antibody that has shown promise for the PET imaging of
cancers expressing carbohydrate antigen 19.9 (CA19.9)—a carbohydrate prevalent in cells …

C5a-mediated release of interleukin 6 by human monocytes

W Scholz, MR McClurg, GJ Cardenas, M Smith… - Clinical immunology and …, 1990 - Elsevier
Recombinant human C5a (rC5a) was assessed for its ability to induce interleukin 6 (IL-6)
production in human peripheral blood-derived mononuclear cell (PBMC) cultures. rC5a was …

Hoe 694, a new Na+/H+ exchange inhibitor and its effects in cardiac ischaemia.

W Scholz, U Albus, HJ Lang, W Linz… - British journal of …, 1993 - ncbi.nlm.nih.gov
The benzoylguanidine derivative Hoe 694 ((3-methylsulphonyl-4-piperidino-benzoyl)
guanidine methanesulphonate) was characterized as an inhibitor of Na+/H+ exchange in rabbit …