… Recommendations will evolve as data are generated on the utility of intermediate end …
databases that will allow validation or refinement of the intermediate end points proposed herein. …

Together, histone acetyltransferases and histone deacetylases (HDACs) determine the
acetylation status of histones. This acetylation affects the regulation of gene expression, and …

Double-stranded (ds) RNA can induce sequence-specific inhibition of gene function in several
organisms. However, both the mechanism and the physiological role of the interference …

… Currently, there are multiple phase II studies in patients with hematologic and solid tumor
malignancies that are exploring the efficacy of daily and twice daily schedules that will help to …

The base sequence of DNA provides the genetic code for proteins. The regulation of
expression or suppression of gene transcription is largely determined by the structure of the …

This is a new book, intended primarily for veterinary students. Its concise form and excellent
photographs should commend it to them; and others will also find it useful. The subject is …

In screening for embryonic-lethal mutations in Caernorhabditis elegans, we defined an
essential gene (let-858) that encodes a nuclear protein rich in acidic and basic residues. We …

The largest subunit of mammalian RNA polymerase II (RNAP II) contains at its carboxyl terminus
an unusual domain consisting of 52 tandem repeats of the consensus sequence Tyr-Ser…

Background Intestinal barrier function is important for preserving health, as a compromised
barrier allows antigen entry and can induce inflammatory diseases. Probiotic bacteria can …

Purpose A randomized, placebo-controlled study based on preclinical and clinical data that
supports the potential role of vascular endothelial growth factor in prostate cancer was …